Presynaptic versus postsynaptic dopamine D2 receptor signaling and neurological/neuropsychiatric disorders
Event details
| Date | 27.10.2010 |
| Hour | 14:00 |
| Speaker | Emiliana BORRELLI, Professor, Dept Microbiology & Molecular Genetics, University of California Irvine, USA |
| Location | |
| Category | Conferences - Seminars |
Dopamine is a major neuromodulator of brain functions as illustrated by the number of neurological (i.e. Parkinson’s disease) and neuropsychiatric (i.e. schizophrenia) disorders that derive from dysregulation of dopamine signaling.
Our laboratory has a longstanding interest in unraveling the complexity of dopamine D2 receptor (D2R)-mediated signaling; these receptors regulate dopamine synthesis, release, firing of dopaminergic neurons as well as postsynaptic responses related to intracellular signaling and regulation of other neurotransmitters release. In addition, D2Rs are the major target of antipsychotics, indicating that D2R-mediated signaling is contributing to the etiology of disorders such as schizophrenia.
Novel findings will be presented, which clarify the role of each specific D2R component in vivo.
Practical information
- General public
- Free