Probing biological systems in a new single-molecule regime

Event details
Date | 03.02.2017 |
Hour | 09:00 › 10:00 |
Speaker | Dr. Peter Maurer, Stanford University |
Location | |
Category | Conferences - Seminars |
Abstract:
Investigating biological systems at the single-molecule level provides insights that are often not accessible through ensemble measurements. Such systems range from heterogeneous and dynamic processes to protein distribution and interaction in cells. In my talk I will discuss the development and application of novel technologies to study biological systems at a single-molecule level. I will start with a general introduction to quantum sensing, which recently has enabled the measurement of magnetic fields at a nanoscale. I will then show how we utilize such sensing techniques to control the temperature profile in living systems with subcellular resolution. Furthermore, I will introduce a multicolor electron microscopy modality that can visualize the absolute location of proteins within the context of cellular ultrastructures with up to ten nanometer spatial resolution. Finally, I will provide an outlook on how quantum sensing and single-molecule biophysics can be utilized to perform nuclear magnetic resonance spectroscopy with unprecedented sensitivity, possible down to the level of individual biomolecules.
Investigating biological systems at the single-molecule level provides insights that are often not accessible through ensemble measurements. Such systems range from heterogeneous and dynamic processes to protein distribution and interaction in cells. In my talk I will discuss the development and application of novel technologies to study biological systems at a single-molecule level. I will start with a general introduction to quantum sensing, which recently has enabled the measurement of magnetic fields at a nanoscale. I will then show how we utilize such sensing techniques to control the temperature profile in living systems with subcellular resolution. Furthermore, I will introduce a multicolor electron microscopy modality that can visualize the absolute location of proteins within the context of cellular ultrastructures with up to ten nanometer spatial resolution. Finally, I will provide an outlook on how quantum sensing and single-molecule biophysics can be utilized to perform nuclear magnetic resonance spectroscopy with unprecedented sensitivity, possible down to the level of individual biomolecules.
Practical information
- Expert
- Free
- This event is internal
Organizer
- Prof. Benoit Deveaud, Institute of Physics
Contact
- Blandine Jérôme