Regulation of mitochondrial homeostasis by metabolism in mitochondria
Event details
| Date | 13.02.2019 |
| Hour | 11:00 › 12:00 |
| Speaker | Junxiang ZHOU Ph.D. in Chonglin Yang’s lab, Institute of Genetics and Developmental Biology (IGDB), Chinese Academy of Sciences |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Mitochondria are central to cell homeostasis by coordinating many catabolic and anabolic pathways and coupling the TCA cycle with ATP production. However, it is largely unknown how aberrant metabolism affect mitochondria. Here we show the requirement for mitochondrial saccharopine degradation in mitochondrial homeostasis and animal development, which provides mechanistic and therapeutic insights for understanding and treating hyperlysinemia II (saccharopinuria), an aminoacidopathy with severe developmental defects. Besides, we demonstrate that defective degradation of D-2HG induces mitochondrial damage by inhibiting the metabolism of propionate, suggesting that mitochondrial dysfunction contributes to D-2HG related metabolic disorders and cancers.
Abstract:
Mitochondria are central to cell homeostasis by coordinating many catabolic and anabolic pathways and coupling the TCA cycle with ATP production. However, it is largely unknown how aberrant metabolism affect mitochondria. Here we show the requirement for mitochondrial saccharopine degradation in mitochondrial homeostasis and animal development, which provides mechanistic and therapeutic insights for understanding and treating hyperlysinemia II (saccharopinuria), an aminoacidopathy with severe developmental defects. Besides, we demonstrate that defective degradation of D-2HG induces mitochondrial damage by inhibiting the metabolism of propionate, suggesting that mitochondrial dysfunction contributes to D-2HG related metabolic disorders and cancers.
Practical information
- Informed public
- Free
Organizer
- Johan Auwerx on behalf of the Lausanne Integrative Metabolism and Nutrition Alliance - LIMNA
Contact
- (*) IMPORTANT NOTICE: All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1142. Contact person to call at arrival at SV Reception Desk: Administrative Assistant: 39522.