Small RNA Silencing in Drosophila
Event details
| Date | 24.04.2009 |
| Hour | 12:15 |
| Speaker | Klaus Förstemann |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
The discovery of gene silencing through miRNAs and siRNAs was an important addition both to our understanding of gene regulation and as a tool to study gene function. Additional classes of small silencing RNAs were discovered through “deep sequencing” technologies; they appear to protect our genome from the mobilization of selfish genetic elements in somatic tissues as well as in the germline. The high copy number and repetitive nature of such elements is shared by stably integrated expression constructs that are frequently used in cell culture. This has allowed us to study the de novo generation of such a silencing response, its mechanism of repression and to analyze specific protein factors which are required for the repression of repetitive elements by small RNAs.
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Practical information
- General public
- Free
Contact
- Joachim Lingner