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U.S. CDMRP – Neurofibromatosis Research Program (NFRP) | Research Funding

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Event details

Date 12.09.2024
Category Call for proposal
Aim: Through the Congressionally Directed Medical Research Program (CDMRP), the Department of Defense is announcing the 2024 Neurofibromatosis Research Program (NFRP). Several award programs are available:
  • The Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of NF. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first-in-human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials through large-scale trials to determine efficacy in relevant patient populations. All applications must specifically address Areas of Emphasis listed in this document.
  • The Early Investigator Research Award supports NF-focused research opportunities for individuals in the early stages of their careers, under the guidance of a Designated Mentor. This opportunity allows for early-stage investigators to develop a research project, investigate a problem or question in NF research, and further their intellectual development as an NF researcher of the future. The postdoctoral investigator is considered the Principal Investigator (PI) of the application and must exhibit strong potential for, and commitment to, pursuing a career as an investigator at the forefront of NF research; however, the PI is not required to have previous NF research experience. All applications must specifically address Areas of Emphasis listed in this document.
  • The Exploration - Hypothesis Development Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in NF research. Studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a wellformulated, testable hypothesis based on strong scientific rationale and study design. All applications must specifically address Areas of Emphasis listed in this document.
  • The Investigator-Initiated Research Award supports highly rigorous, high-impact research projects that have the potential to make an important contribution to NF research and/or patient care. Research projects may focus on any phase of research, excluding clinical trials. The rationale for a research idea may be derived from laboratory discovery, population-based studies, a clinician’s firsthand knowledge of patients, or anecdotal data. All applications must specifically address Areas of Emphasis listed in this document.
  • The New Investigator Award intends to support the continued development of promising Early-Stage Investigators and/or the transition of Established Investigators from other research fields into a career in the field of NF research. Prior experience in NF research is not required. However, Principal Investigators (PIs) with a limited background in NF research are strongly encouraged to have a collaborator who is experienced in the NF field. All applications must specifically address Areas of Emphasis listed in this document.
  • The Synergistic Idea Award supports new ideas that represent synergistic approaches to NF research involving two or three Principal Investigators (PIs). These investigators should utilize their complementary and synergistic perspectives to address a central problem or question in NF research. This award is designed to support both new and pre-existing partnerships and encourages participation of PIs from other research fields. Applications must include preliminary and/or published data that are relevant to NF and the proposed research project. All applications must specifically address Areas of Emphasis listed in this document.

Funding:
  • Clinical Trial Award: $800,000 - $1M
  • Early Investigator Research Award: $200,000
  • Exploration - Hypothesis Development Award: $100,000
  • Investigator-Initiated Research Award: $575,000
  • New Investigator Award: $450,000
  • Synergistic Idea Award: $2M

Duration:     
  • Clinical Trial Award: 4 years
  • Early Investigator Research Award: 2 years
  • Exploration - Hypothesis Development Award: 2 years
  • Investigator-Initiated Research Award: 3 years
  • New Investigator Award: 3 years
  • Synergistic Idea Award: 3 years

Eligibility: Applicants from international organizations or institutions are eligible to apply, and there are no citizenship restrictions.

How to Apply: Pre-applications are submitted through the eBRAP platform. They should contain contact information, a letter of intent, and a list of collaborators and key personnel as suggested on the platform. Full applications will be made via a Grants.gov workspace. Application packages can be downloaded from Grants.gov at any time.

Pre-Application Deadline:
    12 September 2024, 5:00 p.m. Eastern time

Full Application Deadline:
    03 October 2024, 11:59 p.m Eastern Time
                                                          
Further information:

Practical information

  • Informed public
  • Free

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