Using DNA Origami to Decipher Spatial Effects in Biology
Event details
| Date | 04.03.2019 |
| Hour | 12:15 |
| Speaker | Prof. Björn Högberg, Karolinska Institute, Stockholm (SE) |
| Location | |
| Category | Conferences - Seminars |
WEEKLY BIOENGINEERING COLLOQUIA SERIES
(sandwiches served)
Abstract:
It is widely accepted that the biophysical context of ligands and receptors has significant impact of downstream signaling, however the concept is poorly understood due to difficulties in controlling and analyzing the microenvironment on the nanoscale. I will talk about how we think that DNA-nanotechnology can be of great help in both learning the tactile alphabet of cells by stimulation using protein decorated DNA-origami ‘nano-calipers’ and of help in understanding the binding of antibodies. I will also briefly present our recent work on ‘3D-printing’ DNA origami wireframe structures, a method that provides a way to make origami more accessible to experiments in physiological salt conditions.
Bio:
Björn Högberg is a professor of molecular systems biophysics and head of the Division of Biomaterials at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet. He is a Knut and Alice Wallenberg Foundation Academy Fellow and an ERC Consolidator grantee.
Högberg’s research is focused on developing new methods and molecular tools for cell biology research using DNA devices, mainly DNA nanotechnology and DNA origami. His focus has been both in development of the basic technology and in applications to probe and manipulate cell signaling by cell surface receptor clustering. His research also involve using these devices for drug delivery in cancer.
Högberg earned his MSc in Physics at Uppsala University and did his PhD in Physics both at Chalmers University, where he started, and at Mid Sweden University where he graduated in 2007. After that he joined the lab of William Shih as a post-doc at Harvard Medical School and Dana Farber Cancer Institute in Boston, USA. He joined Karolinska Institutet in 2010 as an Assistant Professor at the dept. of Neuroscience and now holds a faculty positon at the dept. of Medical Biochemistry and Biophysics.
‘Zoom’ link for attending remotely: https://epfl.zoom.us/j/331009416
(sandwiches served)
Abstract:
It is widely accepted that the biophysical context of ligands and receptors has significant impact of downstream signaling, however the concept is poorly understood due to difficulties in controlling and analyzing the microenvironment on the nanoscale. I will talk about how we think that DNA-nanotechnology can be of great help in both learning the tactile alphabet of cells by stimulation using protein decorated DNA-origami ‘nano-calipers’ and of help in understanding the binding of antibodies. I will also briefly present our recent work on ‘3D-printing’ DNA origami wireframe structures, a method that provides a way to make origami more accessible to experiments in physiological salt conditions.
Bio:
Björn Högberg is a professor of molecular systems biophysics and head of the Division of Biomaterials at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet. He is a Knut and Alice Wallenberg Foundation Academy Fellow and an ERC Consolidator grantee.
Högberg’s research is focused on developing new methods and molecular tools for cell biology research using DNA devices, mainly DNA nanotechnology and DNA origami. His focus has been both in development of the basic technology and in applications to probe and manipulate cell signaling by cell surface receptor clustering. His research also involve using these devices for drug delivery in cancer.
Högberg earned his MSc in Physics at Uppsala University and did his PhD in Physics both at Chalmers University, where he started, and at Mid Sweden University where he graduated in 2007. After that he joined the lab of William Shih as a post-doc at Harvard Medical School and Dana Farber Cancer Institute in Boston, USA. He joined Karolinska Institutet in 2010 as an Assistant Professor at the dept. of Neuroscience and now holds a faculty positon at the dept. of Medical Biochemistry and Biophysics.
‘Zoom’ link for attending remotely: https://epfl.zoom.us/j/331009416
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI), Christina Mattsson