retrieve:
Return the details about the given Event id.

list:
List all Event objects.

GET /api/v1/events/?format=api&offset=80&ordering=event__place_and_room
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept

{
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        {
            "id": 70922,
            "title": "Une éducation au réel. L'Atelier Cantàfora à l'EPFL / ARCHIZOOM",
            "slug": "une-education-au-reel-l-atelier-cantafora-a-l-epfl",
            "event_url": "https://memento.epfl.ch/event/une-education-au-reel-l-atelier-cantafora-a-l-epfl",
            "visual_url": "https://memento.epfl.ch/image/32310/200x112.jpg",
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            "visual_maxsize_url": "https://memento.epfl.ch/image/32310/max-size.jpg",
            "lang": "en",
            "start_date": "2026-03-17",
            "end_date": "2026-06-05",
            "start_time": null,
            "end_time": null,
            "description": "<strong>UNE ÉDUCATION AU RÉEL <br>\r\nL’ATELIER CANTÀFORA<br>\r\n18.03-05.06.2026<br>\r\n<br>\r\nOpening! Tuesday 17 March 6.30 pm</strong><br>\r\n<br>\r\nThis exhibition explores the vast field of graphic representation in architecture through fifteen years of teaching architectural representation at EPFL at the turn of the 2000s. It presents around a hundred paintings on wood, didactic works produced between 1997 and 2007 in the teaching units of the painter Arduino Cantàfora. They suggest a possible way of making, between thought and <em>actio</em>, where drawing and painting structure a concept and become an essential language for expressing the founding idea of a project. Despite the transition to digital technology, the exhibition conveys the conviction that the artisanal culture of drawing and painting continues to play a fundamental and indispensable role in training architects.<br>\r\n<br>\r\n<em>An exhibition produced in collaboration with the LAPIS laboratory at the EPFL’s Institute of Architecture and Urban Planning.</em>",
            "image_description": "",
            "creation_date": "2026-01-20T19:05:53",
            "last_modification_date": "2026-01-26T08:24:30",
            "link_label": "Une éducation au réel. L'Atelier Cantàfora",
            "link_url": "https://www.epfl.ch/campus/art-culture/museum-exhibitions/archizoom/fr/une-education-au-reel-latelier-cantafora-2/",
            "canceled": "False",
            "cancel_reason": "",
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            "url_place_and_room": "https://plan.epfl.ch/?room==SG%201212",
            "url_online_room": "",
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            "speaker": "LAPIS",
            "organizer": "Archizoom",
            "contact": "Solène Hoffmann",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
                "id": 1,
                "fr_label": "Tout public",
                "en_label": "General public"
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                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "Architecture, dessin, figuration graphique, peinture",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/119394/",
            "category": {
                "id": 5,
                "code": "EXPO",
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        {
            "id": 70945,
            "title": "Une éducation au réel. L'Atelier Cantàfora à l'EPFL / ARCHIZOOM",
            "slug": "une-education-au-reel-l-atelier-cantafora-a-l-ep-4",
            "event_url": "https://memento.epfl.ch/event/une-education-au-reel-l-atelier-cantafora-a-l-ep-4",
            "visual_url": "https://memento.epfl.ch/image/32333/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/32333/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/32333/max-size.jpg",
            "lang": "en",
            "start_date": "2026-04-14",
            "end_date": "2026-04-14",
            "start_time": "17:30:00",
            "end_time": null,
            "description": "<strong>UNE ÉDUCATION AU RÉEL <br>\r\nL’ATELIER CANTÀFORA<br>\r\n18.03-05.06.2026</strong><br>\r\n<br>\r\nGuided tour by Nicola Braghieri<br>\r\nFollowed by a School Lecture by Truwant + Rodet +<br>\r\n<br>\r\nThis exhibition explores the vast field of graphic representation in architecture through fifteen years of teaching architectural representation at EPFL at the turn of the 2000s. It presents around a hundred paintings on wood, didactic works produced between 1997 and 2007 in the teaching units of the painter Arduino Cantàfora. They suggest a possible way of making, between thought and <em>actio</em>, where drawing and painting structure a concept and become an essential language for expressing the founding idea of a project. Despite the transition to digital technology, the exhibition conveys the conviction that the artisanal culture of drawing and painting continues to play a fundamental and indispensable role in training architects.<br>\r\n<br>\r\n<em>An exhibition produced in collaboration with the LAPIS laboratory at the EPFL’s Institute of Architecture and Urban Planning.</em><br>\r\n<br>\r\nGuided tours are available upon <a href=\"https://forms.gle/gev6sJt7sk9V4xFP9\">registration</a>. <br>\r\nGuided tours can be organized upon request for groups and schools. ",
            "image_description": "",
            "creation_date": "2026-01-26T08:31:05",
            "last_modification_date": "2026-01-26T08:31:05",
            "link_label": "Visite guidée",
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            "canceled": "False",
            "cancel_reason": "",
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            "url_online_room": "",
            "spoken_languages": [
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            ],
            "speaker": "Nicola Braghieri",
            "organizer": "Archizoom    ",
            "contact": "Solène Hoffmann",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
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                "fr_label": "Tout public",
                "en_label": "General public"
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                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "Architecture, urbanisme, représentation, dessin, peinture",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/119431/",
            "category": {
                "id": 4,
                "code": "DIVERS",
                "fr_label": "Autres types d’événement",
                "en_label": "Miscellaneous",
                "activated": true
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                "https://memento.epfl.ch/api/v1/mementos/45/?format=api"
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        {
            "id": 70947,
            "title": "Des Cèdres à Dorigny, bâtir l'école d'architecture / ACM ARCHIZOOM",
            "slug": "des-cedres-a-dorigny-batir-l-ecole-d-architectur-2",
            "event_url": "https://memento.epfl.ch/event/des-cedres-a-dorigny-batir-l-ecole-d-architectur-2",
            "visual_url": "https://memento.epfl.ch/image/32335/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/32335/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/32335/max-size.jpg",
            "lang": "en",
            "start_date": "2026-03-04",
            "end_date": "2026-09-29",
            "start_time": null,
            "end_time": null,
            "description": "<strong>DES CÈDRES À DORIGNY, <br>\r\nBÂTIR L’ÉCOLE D’ARCHITECTURE<br>\r\n04.03-29.09.2026<br>\r\n<br>\r\nOpening! Tuesday 3 March 6.30pm</strong><br>\r\n<br>\r\nFocusing on architectural projects, both built and unrealised, kept in the archives of modern construction, the exhibition <em>Des Cèdres à Dorigny</em> tells the story of the birth and evolution of the Lausanne School of Architecture. From its beginnings within the EPUL to its integration into the EPFL campus, this historical journey puts into perspective the conditions of architectural education, its relationship with engineering, and the role of archives in building an institutional memory that sheds light on both the discipline of architecture and its teaching.<br>\r\n<br>\r\n<em>An exhibition produced in collaboration with the <a href=\"https://www.epfl.ch/schools/enac/acm/en/acm-en/\">Archives de la construction moderne</a> at EPFL</em>",
            "image_description": "",
            "creation_date": "2026-01-26T08:56:11",
            "last_modification_date": "2026-02-18T11:08:55",
            "link_label": "Dès Cèdes à Dorigny, bâtir l'école d'architecture",
            "link_url": "https://www.epfl.ch/campus/art-culture/museum-exhibitions/archizoom/fr/des-cedres-a-dorigny-batir-lecole-darchitecture/",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "Archizoom",
            "url_place_and_room": "https://plan.epfl.ch/?room==SG%201212",
            "url_online_room": "",
            "spoken_languages": [
                "https://memento.epfl.ch/api/v1/spoken_languages/1/?format=api",
                "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api"
            ],
            "speaker": "ACM    ",
            "organizer": "ARCHIZOOM ACM",
            "contact": "Solène Hoffmann",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
                "id": 1,
                "fr_label": "Tout public",
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            },
            "registration": {
                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "Architecture, enseignement, campus EPFL, archives",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/119435/",
            "category": {
                "id": 5,
                "code": "EXPO",
                "fr_label": "Expositions",
                "en_label": "Exhibitions",
                "activated": true
            },
            "academic_calendar_category": null,
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                "https://memento.epfl.ch/api/v1/mementos/6/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/22/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/32/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/45/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/145/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/421/?format=api"
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        },
        {
            "id": 71168,
            "title": "International Archives Day / ACM ARCHIZOOM",
            "slug": "international-archives-day-acm-archizoom",
            "event_url": "https://memento.epfl.ch/event/international-archives-day-acm-archizoom",
            "visual_url": "https://memento.epfl.ch/image/32536/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/32536/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/32536/max-size.jpg",
            "lang": "en",
            "start_date": "2026-06-09",
            "end_date": "2026-06-09",
            "start_time": "17:00:00",
            "end_time": null,
            "description": "<strong>Tuesday 9 June 5 pm<br>\r\nGuided tour of the <a href=\"https://www.epfl.ch/schools/enac/acm/en/acm-en/\"><em>Archives de la Construction Moderne</em></a> followed by a guided tour of the exhibition <a href=\"https://www.epfl.ch/campus/art-culture/museum-exhibitions/archizoom/des-cedres-a-dorigny-batir-lecole-darchitecturefrom-cedres-to-dorigny/\"><em>Des Cèdres à Dorigny, bâtir l'école d'architecture</em></a></strong><br>\r\n<br>\r\nInternational Archives Day is a global event established by the International Council on Archives in 2005 to raise awareness of the role of archives and highlight the work of archivists. To mark the occasion, the Archives de la Construction Moderne and Archizoom invite you to take a tour that begins with the ACM's original document storage facilities and ends with their display at Archizoom with the exhibition <em>Des Cèdres à Dorigny, bâtir l'école d'architecture</em>.<br>\r\n<br>\r\n<strong>About the exhibition </strong><br>\r\n<br>\r\nFocusing on architectural projects, both built and unrealised, kept in the archives of modern construction, the exhibition <em>Des Cèdres à Dorigny</em> tells the story of the birth and evolution of the Lausanne School of Architecture. From its beginnings within the EPUL to its integration into the EPFL campus, this historical journey puts into perspective the conditions of architectural education, its relationship with engineering, and the role of archives in building an institutional memory that sheds light on both the discipline of architecture and its teaching.<br>\r\n<br>\r\n<em>Guided tours are available upon <a href=\"https://forms.gle/22MoeLq9n3JDQTb56\">registration</a></em><br>\r\n<em>Guided tours can be organized upon request for groups and schools</em>",
            "image_description": "",
            "creation_date": "2026-02-18T10:55:58",
            "last_modification_date": "2026-02-18T10:59:47",
            "link_label": "Des Cèdres à Dorigny, bâtir l'école d'architecture",
            "link_url": "https://www.epfl.ch/campus/art-culture/museum-exhibitions/archizoom/fr/des-cedres-a-dorigny-batir-lecole-darchitecture/",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "Archizoom",
            "url_place_and_room": "https://plan.epfl.ch/?room==SG%201212",
            "url_online_room": "",
            "spoken_languages": [
                "https://memento.epfl.ch/api/v1/spoken_languages/1/?format=api"
            ],
            "speaker": "Barbara Galimberti, Kethsana Muong",
            "organizer": "Archizoom ACM",
            "contact": "Solène Hoffmann",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
                "id": 1,
                "fr_label": "Tout public",
                "en_label": "General public"
            },
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                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "Journée internationale des archives, architecture, archives, histoire, construction, exposition",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/119774/",
            "category": {
                "id": 9,
                "code": "MANIF",
                "fr_label": "Événements festifs et culturels",
                "en_label": "Cultural events",
                "activated": true
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        {
            "id": 71169,
            "title": "Des Cèdres à Dorigny, bâtir l'école d'architecture / ACM ARCHIZOOM",
            "slug": "des-cedres-a-dorigny-batir-l-ecole-d-architectur-8",
            "event_url": "https://memento.epfl.ch/event/des-cedres-a-dorigny-batir-l-ecole-d-architectur-8",
            "visual_url": "https://memento.epfl.ch/image/32537/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/32537/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/32537/max-size.jpg",
            "lang": "en",
            "start_date": "2026-09-22",
            "end_date": "2026-09-22",
            "start_time": "17:30:00",
            "end_time": null,
            "description": "<strong>DES CÈDRES À DORIGNY, <br>\r\nBÂTIR L’ÉCOLE D’ARCHITECTURE<br>\r\n04.03-29.09.2026<br>\r\n<br>\r\nTuesday 22 September 5.30pm, with an ACM archivist</strong><br>\r\n<br>\r\nFocusing on architectural projects, both built and unrealised, kept in the archives of modern construction, the exhibition <em>Des Cèdres à Dorigny</em> tells the story of the birth and evolution of the Lausanne School of Architecture. From its beginnings within the EPUL to its integration into the EPFL campus, this historical journey puts into perspective the conditions of architectural education, its relationship with engineering, and the role of archives in building an institutional memory that sheds light on both the discipline of architecture and its teaching.<br>\r\n<br>\r\nGuided tours are available upon <a href=\"https://forms.gle/22MoeLq9n3JDQTb56\">registration</a><br>\r\nGuided tours can be organized upon request for groups and schools<br>\r\n<br>\r\nAn exhibition produced in collaboration with the <a href=\"https://www.epfl.ch/schools/enac/acm/en/acm-en/\">Archives de la construction moderne</a> at EPFL",
            "image_description": "",
            "creation_date": "2026-02-18T11:07:37",
            "last_modification_date": "2026-02-18T11:07:37",
            "link_label": "",
            "link_url": "",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "Archizoom",
            "url_place_and_room": "https://plan.epfl.ch/?room==SG%201212",
            "url_online_room": "",
            "spoken_languages": [
                "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api"
            ],
            "speaker": "Kethsana Muong",
            "organizer": "Archizoom ACM",
            "contact": "Solène Hoffmann",
            "is_internal": "False",
            "theme": "",
            "vulgarization": {
                "id": 1,
                "fr_label": "Tout public",
                "en_label": "General public"
            },
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                "id": 3,
                "fr_label": "Entrée libre",
                "en_label": "Free"
            },
            "keywords": "Architecture, Archives, Archives de la construction moderne, EPFL, Histoire",
            "file": null,
            "icalendar_url": "https://memento.epfl.ch/event/export/119776/",
            "category": {
                "id": 9,
                "code": "MANIF",
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                "https://memento.epfl.ch/api/v1/mementos/6/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/22/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/32/?format=api",
                "https://memento.epfl.ch/api/v1/mementos/45/?format=api",
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        },
        {
            "id": 71098,
            "title": "AI for Clinical and Translational Medicine",
            "slug": "ai-for-clinical-and-translational-medicine",
            "event_url": "https://memento.epfl.ch/event/ai-for-clinical-and-translational-medicine",
            "visual_url": "https://memento.epfl.ch/image/32471/200x112.jpg",
            "visual_large_url": "https://memento.epfl.ch/image/32471/720x405.jpg",
            "visual_maxsize_url": "https://memento.epfl.ch/image/32471/max-size.jpg",
            "lang": "en",
            "start_date": "2026-05-06",
            "end_date": "2026-05-06",
            "start_time": null,
            "end_time": null,
            "description": "<strong>2nd edition of the Symposium AI for Clinical and Translational Medicine </strong>on<strong> May 6<sup>th</sup>, 2026</strong>. Organized by the <strong>Biomedical Data Science Center-CHUV</strong>, the event will bring together leading experts to highlight the latest advances in artificial intelligence and the digital innovations transforming medical research and healthcare.<br>\r\n<br>\r\nJoin us for a day of insightful presentations and discussions on the future of data‑driven medicine.<br>\r\n<br>\r\nThis year’s program will feature keynote lectures by <strong>Jonah COOL, X. Shirley LIU, and Pranav RAJPURKAR</strong>, offering unique insights into the future of data-driven medicine.<br>\r\n<br>\r\n<strong>More info and registration: https://www.unil.ch/events/en/1773836724181</strong><br>\r\n<br>\r\n<br>\r\n ",
            "image_description": "",
            "creation_date": "2026-02-10T15:11:44",
            "last_modification_date": "2026-03-19T10:36:10",
            "link_label": "Info and registration",
            "link_url": "https://www.unil.ch/events/en/1773836724181",
            "canceled": "False",
            "cancel_reason": "",
            "place_and_room": "Auditorium Cesar Roux - CHUV",
            "url_place_and_room": "",
            "url_online_room": "",
            "spoken_languages": [
                "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api"
            ],
            "speaker": "<strong>Jonah COOL, X. Shirley LIU, and Pranav RAJPURKAR</strong>",
            "organizer": "Biomedical Data Science Center (BDSC)",
            "contact": "<a href=\"http://[email protected]\">Marielle Girardin</a>",
            "is_internal": "False",
            "theme": "",
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                "id": 3,
                "fr_label": "Expert",
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            },
            "registration": {
                "id": 1,
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            "title": "G protein-coupled receptors functional dynamics revealed by experimental and computational structural data",
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            "start_date": "2026-10-07",
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            "description": "<p>You can apply to participate and find all the relevant information (speakers, abstracts, program,...) on the event website: <a href=\"https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488\">https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488</a>.<br>\r\n<br>\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any).  However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the <a href=\"mailto:[email protected]\">CECAM Event Manager</a> if you have any question.<br>\r\n<br>\r\n<strong>Description</strong><br>\r\n<br>\r\nG protein-coupled receptors (GPCRs) represent a vast and diverse class of transmembrane proteins that orchestrate a wide range of physiological processes by responding to both endogenous and exogenous ligands [1,2]. These receptors are essential to critical functions such as metabolism, immune regulation, neuronal signaling, and sensory perception - including vision and olfaction. Due to their physiological relevance and membrane accessibility, GPCRs are the targets of approximately 34% of all prescribed medications, accounting for nearly 27% of the global pharmaceutical market [3]. <br>\r\nDespite their pharmaceutical importance, key aspects of GPCR function remain elusive. The canonical activation model posits that agonist binding to the extracellular orthosteric site triggers allosteric changes - most notably, the outward displacement of transmembrane helices 5 (TM5) and 6 (TM6) on the intracellular side - ultimately leading to receptor activation [2-4]. However, recent evidence suggests a more nuanced mechanism. In several GPCRs, activation appears to involve cooperative engagement between the agonist and the G protein. For example, the G protein may disrupt an \"inactivating ionic lock\" - a salt bridge between TM3 and TM6 - while the agonist stabilizes the active conformation. In some receptors, this is complemented by the formation of an “activating ionic lock” between TM5 and TM6 [5-8]. These dual contributions are considered thermodynamically essential for full activation [7].<br>\r\nAdding further complexity, GPCR activity is regulated by conformational microswitches and finely tuned intra-protein interaction networks. These dynamic rearrangements are difficult to capture and often elude direct correlation with functional outcomes. Moreover, allosteric ligands - which bind sites distinct from the orthosteric pocket - are being increasingly identified [9-12], along with small molecules capable of biased signaling, i.e., preferential activation of specific intracellular pathways [11-13, 16, 17]. These findings reveal a rich and underexplored conformational landscape that governs GPCR signaling. In addition, native membrane components—such as lipids and interacting proteins, including GPCR oligomers—are known to significantly modulate receptor function [11, 18-22].<br>\r\nTo disentangle these intricacies, computational modeling has become indispensable, offering atomistic insight into GPCR conformational dynamics and mechanistic understanding [1-2, 7, 11, 14, 16–21, 23]. Nevertheless, key questions remain - particularly regarding the structural basis of biased signaling, strategies for leveraging allosteric networks in pharmacology, and the modulatory role of the lipid environment. Addressing these gaps is crucial for both fundamental biology and the rational design of next-generation GPCR-targeting drugs with improved selectivity and safety profiles. <br>\r\nThese scientific challenges form the foundation of our upcoming workshop, which will focus on the latest experimental and computational approaches for studying the functional dynamics of GPCRs. Given the profound health, economic, and societal implications of modulating these receptors with precision, we aim to strengthen the interdisciplinary nature of the event by increasing the representation of experimental research and integrating cutting-edge artificial intelligence applications into the program.<br>\r\nBuilding upon the success of the 2022 and 2024 editions - which led to new collaborations and a landmark publication in <em>Nature Reviews Drug Discovery</em> [24] - our goal is to further enhance communication and collaboration between experimentalists and theoreticians. The workshop will serve as a reference point for young scientists and students, offering a platform to interact with leading international experts. We are confident that this initiative will foster insightful discussions and contribute meaningfully to advancing the field of GPCR pharmacology.<br>\r\n<br>\r\n<strong>References</strong><br>\r\n<br>\r\n<a href=\"https://doi.org/10.1038/nrd.2017.229\" target=\"_blank\">[1] J. Smith, R. Lefkowitz, S. Rajagopal, Nat. Rev. Drug. Discov., <strong>17</strong>, 243-260 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41573-024-01083-3\" target=\"_blank\">[2] P. Conflitti, E. Lyman, M. Sansom, P. Hildebrand, H. Gutiérrez-de-Terán, P. Carloni, T. Ansell, S. Yuan, P. Barth, A. Robinson, C. Tate, D. Gloriam, S. Grzesiek, M. Eddy, S. Prosser, V. Limongelli, Nat. Rev. Drug. Discov., <strong>24</strong>, 251-275 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41589-024-01682-6\" target=\"_blank\">[3] L. Picard, A. Orazietti, D. Tran, A. Tucs, S. Hagimoto, Z. Qi, S. Huang, K. Tsuda, A. Kitao, A. Sljoka, R. Prosser, Nat. Chem. Biol., <strong>21</strong>, 71-79 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.drudis.2020.10.006\" target=\"_blank\">[4] B. Huang, C. St. Onge, H. Ma, Y. Zhang, Drug Discovery Today, <strong>26</strong>, 189-199 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-023-42082-z\" target=\"_blank\">[5] D. Di Marino, P. Conflitti, S. Motta, V. Limongelli, Nat. Commun., <strong>14</strong>, 6439 (2023)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.ceb.2018.10.007\" target=\"_blank\">[6] G. Milligan, R. Ward, S. Marsango, Current Opinion in Cell Biology, <strong>57</strong>, 40-47 (2019)</a><br>\r\n<a href=\"https://doi.org/10.7554/elife.73901\" target=\"_blank\">[7] S. Huang, O. Almurad, R. Pejana, Z. Morrison, A. Pandey, L. Picard, M. Nitz, A. Sljoka, R. Prosser, eLife, <strong>11</strong>, (2022)</a><br>\r\n<a href=\"https://doi.org/10.1146/annurev-pharmtox-010919-023411\" target=\"_blank\">[8] A. Duncan, W. Song, M. Sansom, Annu. Rev. Pharmacol. Toxicol., <strong>60</strong>, 31-50 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-025-60003-0\" target=\"_blank\">[9] A. Morales-Pastor, T. Miljuš, M. Dieguez-Eceolaza, T. Stępniewski, V. Ledesma-Martin, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, D. Sykes, C. Nicholson, E. Koers, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent, Nat. Commun., <strong>16</strong>, 5265 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-022-05588-y\" target=\"_blank\">[10] A. Faouzi, H. Wang, S. Zaidi, J. DiBerto, T. Che, Q. Qu, M. Robertson, M. Madasu, A. El Daibani, B. Varga, T. Zhang, C. Ruiz, S. Liu, J. Xu, K. Appourchaux, S. Slocum, S. Eans, M. Cameron, R. Al-Hasani, Y. Pan, B. Roth, J. McLaughlin, G. Skiniotis, V. Katritch, B. Kobilka, S. Majumdar, Nature, <strong>613</strong>, 767-774 (2022)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-022-31652-2\" target=\"_blank\">[11] M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, E. Dean, C. Hume, S. Hayward, J. Oliver, F. Zhao, D. Spanswick, C. Reynolds, M. Lochner, G. Ladds, B. Frenguelli, Nat. Commun., <strong>13</strong>, 4150 (2022)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41580-018-0049-3\" target=\"_blank\">[12] D. Wootten, A. Christopoulos, M. Marti-Solano, M. Babu, P. Sexton, Nat. Rev. Mol. Cell. Biol., <strong>19</strong>, 638-653 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41594-017-0011-7\" target=\"_blank\">[13] D. Hilger, M. Masureel, B. Kobilka, Nat. Struct. Mol. Biol., <strong>25</strong>, 4-12 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-025-57034-y\" target=\"_blank\">[14] D. Aranda-García, T. Stepniewski, M. Torrens-Fontanals, A. García-Recio, M. Lopez-Balastegui, B. Medel-Lacruz, A. Morales-Pastor, A. Peralta-García, M. Dieguez-Eceolaza, D. Sotillo-Nuñez, T. Ding, M. Drabek, C. Jacquemard, J. Jakowiecki, W. Jespers, M. Jiménez-Rosés, V. Jun-Yu-Lim, A. Nicoli, U. Orzel, A. Shahraki, J. Tiemann, V. Ledesma-Martin, F. Nerín-Fonz, S. Suárez-Dou, O. Canal, G. Pándy-Szekeres, J. Mao, D. Gloriam, E. Kellenberger, D. Latek, R. Guixà-González, H. Gutiérrez-de-Terán, I. Tikhonova, P. Hildebrand, M. Filizola, M. Babu, A. Di Pizio, S. Filipek, P. Kolb, A. Cordomi, T. Giorgino, M. Marti-Solano, J. Selent, Nat. Commun., <strong>16</strong>, 2020 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-018-0259-z\" target=\"_blank\">[15] D. Thal, A. Glukhova, P. Sexton, A. Christopoulos, Nature, <strong>559</strong>, 45-53 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.tips.2020.12.005\" target=\"_blank\">[16] L. Slosky, M. Caron, L. Barak, Trends in Pharmacological Sciences, <strong>42</strong>, 283-299 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.apsb.2023.07.020\" target=\"_blank\">[17] C. Zhu, X. Lan, Z. Wei, J. Yu, J. Zhang, Acta Pharmaceutica Sinica B, <strong>14</strong>, 67-86 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.chempr.2024.08.004\" target=\"_blank\">[18] V. D’Amore, P. Conflitti, L. Marinelli, V. Limongelli, Chem, <strong>10</strong>, 3678-3698 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41557-023-01238-6\" target=\"_blank\">[19] A. Mafi, S. Kim, W. Goddard, Nat. Chem., <strong>15</strong>, 1127-1137 (2023)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41594-024-01334-2\" target=\"_blank\">[20] H. Batebi, G. Pérez-Hernández, S. Rahman, B. Lan, A. Kamprad, M. Shi, D. Speck, J. Tiemann, R. Guixà-González, F. Reinhardt, P. Stadler, M. Papasergi-Scott, G. Skiniotis, P. Scheerer, B. Kobilka, J. Mathiesen, X. Liu, P. Hildebrand, Nat. Struct. Mol. Biol., <strong>31</strong>, 1692-1701 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.cell.2015.04.043\" target=\"_blank\">[21] A. Manglik, T. Kim, M. Masureel, C. Altenbach, Z. Yang, D. Hilger, M. Lerch, T. Kobilka, F. Thian, W. Hubbell, R. Prosser, B. Kobilka, Cell, <strong>161</strong>, 1101-1111 (2015)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.cell.2020.03.003\" target=\"_blank\">[22] M. Congreve, C. de Graaf, N. Swain, C. Tate, Cell, <strong>181</strong>, 81-91 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41573-025-01139-y\" target=\"_blank\">[23] J. Lorente, A. Sokolov, G. Ferguson, H. Schiöth, A. Hauser, D. Gloriam, Nat. Rev. Drug. Discov., <strong>24</strong>, 458-479 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1111/bph.16495\" target=\"_blank\">[24] M. Lopez‐Balastegui, T. Stepniewski, M. Kogut‐Günthel, A. Di Pizio, M. Rosenkilde, J. Mao, J. Selent, British. J. Pharmacology., <strong>182</strong>, 3211-3224 (2024)</a>\r\n</p><div class=\"active tab-pane\"> </div>",
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            "place_and_room": "Aula Magna, USI Lugano",
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            "id": 70957,
            "title": "From Data to Dynamics: Machine Learning in Statistical Mechanics and Molecular Simulations",
            "slug": "from-data-to-dynamics-machine-learning-in-statis-2",
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            "description": "<p>You can apply to participate and find all the relevant information (speakers, abstracts, program,...) on the event website: <a href=\"https://www.cecam.org/workshop-details/from-data-to-dynamics-machine-learning-in-statistical-mechanics-and-molecular-simulations-1487\">https://www.cecam.org/workshop-details/from-data-to-dynamics-machine-learning-in-statistical-mechanics-and-molecular-simulations-1487</a>.<br>\r\n<br>\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any).  However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the <a href=\"mailto:[email protected]\">CECAM Event Manager</a> if you have any question.<br>\r\n<br>\r\n<strong>Description</strong><br>\r\nSince its introduction in the 1970s, molecular dynamics (MD) has become an indispensable computational microscope for studying complex biological systems at atomic resolution. It has enabled detailed investigations into protein folding, conformational dynamics, and ligand binding and unbinding. Over the past decade, increasing computational power has made microsecond-scale simulations routine, producing massive datasets that demand sophisticated analysis strategies [1]. Despite these advances, conventional MD simulations still face a fundamental limitation: many biologically relevant events occur over milliseconds to seconds—timescales largely inaccessible to standard MD.<br>\r\nTo bridge this gap, researchers increasingly turn to enhanced sampling techniques—such as metadynamics and umbrella sampling [2,3]—and coarse-grained (CG) modeling approaches [4]. These methods enable more comprehensive exploration of the system’s free energy landscape, yet their success critically depends on the selection of appropriate reaction coordinates or collective variables (CVs). CVs must capture the slowest, most functionally relevant motions to accurately reflect thermodynamic and kinetic behavior. However, identifying suitable CVs remains one of the field’s most challenging tasks, typically requiring domain expertise and iterative refinement [5, 6].<br>\r\nThis complexity has fueled growing interest in machine learning (ML) techniques, which are now transforming how MD simulations are analyzed, interpreted, and even conducted. ML methods have been applied to automate CV discovery, perform dimensionality reduction, build thermodynamic and kinetic models, and enhance sampling efficiency [7]. These models often employ artificial neural networks or graph neural networks to map high-dimensional molecular configurations—such as Cartesian coordinates or molecular descriptors—into low-dimensional representations suitable for analysis [8].<br>\r\nDepending on the structure and type of data, ML algorithms can be broadly categorized into supervised, unsupervised, and reinforcement learning paradigms [9]. Supervised learning uses labeled input-output pairs to predict properties such as molecular energies or binding affinities [10], while unsupervised learning enables the identification of latent features, such as CVs, directly from data [11].<br>\r\nA cornerstone of modern ML-driven simulation is the development of symmetry-aware molecular representations. The predictive power of ML models hinges on encoding physical symmetries—like rotation and translation—directly into the model. E(3)-equivariant neural networks have emerged as powerful tools for this purpose, significantly improving data efficiency and generalization in learning potential energy surfaces [12]. Ongoing research continues to explore the optimal balance between enforcing strict symmetry and retaining model flexibility.<br>\r\nMeanwhile, breakthroughs in structural prediction—most notably the advent of AlphaFold 3—have revolutionized how researchers obtain initial molecular configurations. AlphaFold now provides remarkably accurate models of not only proteins but also their complexes with nucleic acids, ions, and small-molecule ligands [13]. However, these are static snapshots. They cannot capture dynamic behaviors, allosteric transitions, or binding kinetics—areas where physics-based simulations remain indispensable. Initial benchmarks suggest that even state-of-the-art predictors still fall short in modeling protein dynamics and ranking ligand binding affinities, further emphasizing the role of MD [14].<br>\r\nTo address the dimensionality and sampling bottlenecks, unsupervised ML approaches such as time-lagged autoencoders have reframed CV identification as a data-driven task. More recently, generative models—including diffusion models and variational autoencoders—have emerged as a new frontier. These models can learn the full conformational landscape of biomolecules and enable enhanced sampling, in some cases eliminating the need for predefined CVs altogether [15].<br>\r\nOnce accurate structural models and CVs are established, ML can significantly improve the estimation of thermodynamic and kinetic properties. In drug discovery, for instance, predicting protein–ligand binding affinity remains a central challenge. ML potentials trained on quantum mechanical data can be combined with enhanced sampling to yield highly accurate free energy landscapes and binding kinetics—results previously unattainable due to computational limitations [16]. However, challenges in data quality, model interpretability, and transferability remain critical areas of ongoing investigation [17].<br>\r\nFinally, ML is driving a renaissance in CG modeling. Deep neural networks can now learn many-body CG potentials directly from all-atom simulations, capturing emergent properties and enhancing transferability [18]. These models open the door to longer, larger-scale simulations with greater physical accuracy.<br>\r\nIn this rapidly evolving context, it becomes imperative to critically assess both the promise and limitations of ML in biomolecular simulation. The excitement surrounding these developments must be tempered by careful validation and benchmarking. This workshop thus serves as a timely opportunity—especially for early-career researchers—to explore these cutting-edge methods, engage in constructive dialogue, and chart new directions in the application of machine learning to molecular dynamics and drug discovery.<br>\r\n <br>\r\n<strong>References</strong><br>\r\n<br>\r\n<a href=\"https://doi.org/10.1103/physrevlett.98.146401\" target=\"_blank\">[1] J. Behler, M. Parrinello, Phys. Rev. Lett., <strong>98</strong>, 146401 (2007)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.sbi.2024.102972\" target=\"_blank\">[2] P. Sahrmann, G. Voth, Current Opinion in Structural Biology, <strong>90</strong>, 102972 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1021/acs.jcim.2c01127\" target=\"_blank\">[3] K. Kříž, L. Schmidt, A. Andersson, M. Walz, D. van der Spoel, J. Chem. Inf. Model., <strong>63</strong>, 412-431 (2023)</a><br>\r\n<a href=\"https://doi.org/10.3389/fmolb.2022.899805\" target=\"_blank\">[4] K. Ahmad, A. Rizzi, R. Capelli, D. Mandelli, W. Lyu, P. Carloni, Front. Mol. Biosci., <strong>9</strong>, (2022)</a><br>\r\n<a href=\"https://doi.org/10.1146/annurev-physchem-083122-125941\" target=\"_blank\">[5] S. Mehdi, Z. Smith, L. Herron, Z. Zou, P. Tiwary, Annual Review of Physical Chemistry, <strong>75</strong>, 347-370 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1101/2025.04.07.647682\" target=\"_blank\">[6] H. Zheng, H. Lin, A. Alade, J. Chen, E. Monroy, M. Zhang, J. Wang, AlphaFold3 in Drug Discovery: A Comprehensive Assessment of Capabilities, Limitations, and Applications, 2025</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-024-07487-w\" target=\"_blank\">[7] J. Abramson, J. Adler, J. Dunger, R. Evans, T. Green, A. Pritzel, O. Ronneberger, L. Willmore, A. Ballard, J. Bambrick, S. Bodenstein, D. Evans, C. Hung, M. O’Neill, D. Reiman, K. Tunyasuvunakool, Z. Wu, A. Žemgulytė, E. Arvaniti, C. Beattie, O. Bertolli, A. Bridgland, A. Cherepanov, M. Congreve, A. Cowen-Rivers, A. Cowie, M. Figurnov, F. Fuchs, H. Gladman, R. Jain, Y. Khan, C. Low, K. Perlin, A. Potapenko, P. Savy, S. Singh, A. Stecula, A. Thillaisundaram, C. Tong, S. Yakneen, E. Zhong, M. Zielinski, A. Žídek, V. Bapst, P. Kohli, M. Jaderberg, D. Hassabis, J. Jumper, Nature, <strong>630</strong>, 493-500 (2024)</a><br>\r\n[8] Fabian B. Fuchs, Daniel E. Worrall, Volker Fischer, Max Welling, NIPS'20: Proceedings of the 34th International Conference on Neural Information Processing Systems, Article No.: 166, Pages 1970 - 1981 (2020)<br>\r\n<a href=\"https://doi.org/10.1080/00268976.2020.1737742\" target=\"_blank\">[9] H. Sidky, W. Chen, A. Ferguson, Molecular Physics, <strong>118</strong>, (2020)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.sbi.2019.12.016\" target=\"_blank\">[10] Y. Wang, J. Lamim Ribeiro, P. Tiwary, Current Opinion in Structural Biology, <strong>61</strong>, 139-145 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-018-0337-2\" target=\"_blank\">[11] K. Butler, D. Davies, H. Cartwright, O. Isayev, A. Walsh, Nature, <strong>559</strong>, 547-555 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1146/annurev-physchem-042018-052331\" target=\"_blank\">[12] F. Noé, A. Tkatchenko, K. Müller, C. Clementi, Annu. Rev. Phys. Chem., <strong>71</strong>, 361-390 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1080/23746149.2021.2006080\" target=\"_blank\">[13] S. Kaptan, I. Vattulainen, Advances in Physics: X, <strong>7</strong>, (2022)</a><br>\r\n<a href=\"https://doi.org/10.1002/wcms.1455\" target=\"_blank\">[14] V. Limongelli, WIREs. Comput. Mol. Sci., <strong>10</strong>, (2020)</a><br>\r\n<a href=\"https://doi.org/10.1021/acs.chemrev.0c01195\" target=\"_blank\">[15] A. Glielmo, B. Husic, A. Rodriguez, C. Clementi, F. Noé, A. Laio, Chem. Rev., <strong>121</strong>, 9722-9758 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.sbi.2018.11.005\" target=\"_blank\">[16] A. Pak, G. Voth, Current Opinion in Structural Biology, <strong>52</strong>, 119-126 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1021/jacs.6b05602\" target=\"_blank\">[17] M. Lelimousin, V. Limongelli, M. Sansom, J. Am. Chem. Soc., <strong>138</strong>, 10611-10622 (2016)</a><br>\r\n<a href=\"https://doi.org/10.3390/e16010163\" target=\"_blank\">[18] C. Abrams, G. Bussi, Entropy, <strong>16</strong>, 163-199 (2013)</a>\r\n</p><div class=\"active tab-pane\"> </div>",
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            "link_label": "From Data to Dynamics: Machine Learning in Statistical Mechanics and Molecular Simulations",
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            "description": "<p>Open-source hardware can play a unique role for the semiconductor industry in the age of sustainable AI. It can enable design reuse, foster collaboration, and support workforce development. ESP (Embedded Scalable Platforms) is an open-source research platform for system-on-chip (SoC) design that combines a modular architecture with an agile design methodology. The ESP architecture simplifies the design and prototyping of heterogeneous chips with multiple RISC-V processor cores and dozens of loosely coupled accelerators, all interconnected by a scalable network-on-chip. The ESP methodology promotes system-level design while accommodating different specification languages and design flows.<br>\r\n<br>\r\nESP's capabilities have enabled a small team, primarily composed of graduate students, to realize two SoCs of increasing complexity, each within a few months. Conceived as a heterogeneous system integration platform and refined through years of teaching at Columbia University, ESP is well suited to advance collaborative engineering across the open-source hardware community.<br>\r\n<br>\r\n<strong>This talk will be followed by a standing lunch in <a href=\"https://plan.epfl.ch/?room==BC%20420\">BC420</a> from 12:15 to 13:30.</strong></p>",
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