Event List
retrieve:
Return the details about the given Event id.
list:
List all Event objects.
GET /api/v1/events/?format=api&offset=80&ordering=slug
{ "count": 238, "next": "https://memento.epfl.ch/api/v1/events/?format=api&limit=10&offset=90&ordering=slug", "previous": "https://memento.epfl.ch/api/v1/events/?format=api&limit=10&offset=70&ordering=slug", "results": [ { "id": 71498, "title": "From Helical Motifs to Oral Drugs: Design Principles for Bioavailable Macrocyclic Peptides", "slug": "from-helical-motifs-to-oral-drugs-design-principle", "event_url": "https://memento.epfl.ch/event/from-helical-motifs-to-oral-drugs-design-principle", "visual_url": "https://memento.epfl.ch/image/32840/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32840/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32840/max-size.jpg", "lang": "en", "start_date": "2026-04-20", "end_date": "2026-04-20", "start_time": "14:15:00", "end_time": "15:15:00", "description": "<p>In this seminar, I will discuss our efforts to design conformationally constrained helical macrocyclic peptides and outline the principles that enable effective targeting of protein–protein interactions beyond classical stapled peptides. In the second part, I will show how a subtle isosteric backbone modification—thioamidation—can be used to impart oral bioavailability to bioactive macrocyclic peptides. I will further illustrate how conformational restriction enhances membrane permeability and highlight the critical role of metabolic stability in achieving oral bioavailability.</p>", "image_description": "Prof. Jayanta Chatterjee", "creation_date": "2026-03-30T19:14:23", "last_modification_date": "2026-03-30T19:24:00", "link_label": "Publications Prof. Jayanta Chatterjee", "link_url": "https://scholar.google.com/citations?user=r0aQPNIAAAAJ&hl=en", "canceled": "False", "cancel_reason": "", "place_and_room": "BCH 3118", "url_place_and_room": "https://plan.epfl.ch/?room==BCH%203118", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "Prof. Jayanta Chatterjee, Indian Institute of Science, Bangalore, India", "organizer": "C. Heinis", "contact": "C. Heinis", "is_internal": "False", "theme": "", "vulgarization": { "id": 2, "fr_label": "Public averti", "en_label": "Informed public" }, "registration": { "id": 3, "fr_label": "Entrée libre", "en_label": "Free" }, "keywords": "cbseminar", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/120241/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/5/?format=api", "https://memento.epfl.ch/api/v1/mementos/9/?format=api", "https://memento.epfl.ch/api/v1/mementos/14/?format=api" ] }, { "id": 71179, "title": "Full speed... But Where are Women in Formula 1?", "slug": "full-speed-but-where-are-women-in-formula-1", "event_url": "https://memento.epfl.ch/event/full-speed-but-where-are-women-in-formula-1", "visual_url": "https://memento.epfl.ch/image/32754/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32754/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32754/max-size.jpg", "lang": "en", "start_date": "2026-04-27", "end_date": "2026-04-27", "start_time": "18:00:00", "end_time": "21:00:00", "description": "<p>Extreme speed, millimeter precision, cutting-edge engineering, split-second strategic decisions — a world where every detail counts and performance is everything.<br>\r\nBut behind this high-tech spectacle, one question remains:<br>\r\n<br>\r\n<strong>Where are women?</strong><br>\r\n<br>\r\nIn 2026, while F1 embodies innovation and excellence, it remains one of the most male-dominated professional sports.<br>\r\nCoincidence… or a reflection of deeper, systemic mechanisms?<br>\r\n<br>\r\nThe EPFL Alumni Women Club, in partnership with EPFL Alumni, invites you to go beyond the surface, to understand the forces holding women back in F1.<br>\r\n<br>\r\nIn this open discussion, we will tackle the real questions:<br>\r\n— Is Formula 1 truly accessible to everyone?<br>\r\n— Are the barriers cultural, educational, physical… or systemic?<br>\r\n— Who decides today who gets to join the grid?<br>\r\n— And what role do the media, sponsors, and public play in maintaining—or challenging—this imbalance?<br>\r\n<br>\r\nA high-level exchange at the crossroads of sport, technology, and societal issues. This event offers a deep dive into the backstage of an iconic sport, decoding its codes and structures.<br>\r\nThe goal: to understand, but also to explore concrete levers for change.<br>\r\n<br>\r\nWe are honored to welcome key figures from the paddock:<br>\r\n<br>\r\n<strong>- Mattia Binotto</strong> EPFL engineer, Head of Audi F1 Project: Audi officially enters the FIA Formula 1 World Championship in 2026<br>\r\n<strong>- Laura Villars </strong>First woman candidate for FIA presidency 2025, and racing driver<br>\r\n<strong>- Vita Marina</strong> Project Manager of Power Unit Mechanical Systems at Audi Revolut F1 Team<br>\r\n- and <strong>other exclusive guests !</strong><br>\r\n<br>\r\n<strong>And to cap it off:</strong><br>\r\nExperience the new <a href=\"http://epflracingteam.ch/fr/\" rel=\"noopener noreferrer\" target=\"_blank\">EPFL Racing Team</a> car in an exclusive first look, followed by a guided tour of their workshops and laboratories.<br>\r\n<br>\r\nEvent in English</p>", "image_description": "", "creation_date": "2026-02-19T09:33:43", "last_modification_date": "2026-03-19T09:40:36", "link_label": "REGISTRATION", "link_url": "https://epflalumni.ch/fr/event/save-the-date-women-in-formula-1/2026/02/19/1102", "canceled": "False", "cancel_reason": "", "place_and_room": "RLC E1 240", "url_place_and_room": "https://plan.epfl.ch/?room==RLC%20E1%20240", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "", "organizer": "<a href=\"https://epflalumni.ch/fr/group/women-s-club/34/about\" rel=\"noopener noreferrer\" target=\"_blank\">EPFL Alumni Women Club</a> & <a href=\"https://epflalumni.ch/fr\">EPFL Alumni</a>", "contact": "<a href=\"mailto:[email protected]?subject=Full%20speed...%20But%20Where%20are%20Women%20in%20Formula%201%3F\">Emmanuelle Yanguas</a>", "is_internal": "False", "theme": "", "vulgarization": { "id": 1, "fr_label": "Tout public", "en_label": "General public" }, "registration": { "id": 1, "fr_label": "Sur inscription", "en_label": "Registration required" }, "keywords": "", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119794/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/1/?format=api", "https://memento.epfl.ch/api/v1/mementos/8/?format=api", "https://memento.epfl.ch/api/v1/mementos/21/?format=api", "https://memento.epfl.ch/api/v1/mementos/6/?format=api" ] }, { "id": 70956, "title": "G protein-coupled receptors functional dynamics revealed by experimental and computational structural data", "slug": "g-protein-coupled-receptors-functional-dynamics-re", "event_url": "https://memento.epfl.ch/event/g-protein-coupled-receptors-functional-dynamics-re", "visual_url": "https://memento.epfl.ch/image/32345/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32345/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32345/max-size.jpg", "lang": "en", "start_date": "2026-10-07", "end_date": "2026-10-09", "start_time": null, "end_time": null, "description": "<p>You can apply to participate and find all the relevant information (speakers, abstracts, program,...) on the event website: <a href=\"https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488\">https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488</a>.<br>\r\n<br>\r\nRegistration is required to attend the full event, take part in the social activities and present a poster at the poster session (if any). However, the EPFL community is welcome to attend specific lectures without registration if the topic is of interest to their research. Do not hesitate to contact the <a href=\"mailto:[email protected]\">CECAM Event Manager</a> if you have any question.<br>\r\n<br>\r\n<strong>Description</strong><br>\r\n<br>\r\nG protein-coupled receptors (GPCRs) represent a vast and diverse class of transmembrane proteins that orchestrate a wide range of physiological processes by responding to both endogenous and exogenous ligands [1,2]. These receptors are essential to critical functions such as metabolism, immune regulation, neuronal signaling, and sensory perception - including vision and olfaction. Due to their physiological relevance and membrane accessibility, GPCRs are the targets of approximately 34% of all prescribed medications, accounting for nearly 27% of the global pharmaceutical market [3]. <br>\r\nDespite their pharmaceutical importance, key aspects of GPCR function remain elusive. The canonical activation model posits that agonist binding to the extracellular orthosteric site triggers allosteric changes - most notably, the outward displacement of transmembrane helices 5 (TM5) and 6 (TM6) on the intracellular side - ultimately leading to receptor activation [2-4]. However, recent evidence suggests a more nuanced mechanism. In several GPCRs, activation appears to involve cooperative engagement between the agonist and the G protein. For example, the G protein may disrupt an \"inactivating ionic lock\" - a salt bridge between TM3 and TM6 - while the agonist stabilizes the active conformation. In some receptors, this is complemented by the formation of an “activating ionic lock” between TM5 and TM6 [5-8]. These dual contributions are considered thermodynamically essential for full activation [7].<br>\r\nAdding further complexity, GPCR activity is regulated by conformational microswitches and finely tuned intra-protein interaction networks. These dynamic rearrangements are difficult to capture and often elude direct correlation with functional outcomes. Moreover, allosteric ligands - which bind sites distinct from the orthosteric pocket - are being increasingly identified [9-12], along with small molecules capable of biased signaling, i.e., preferential activation of specific intracellular pathways [11-13, 16, 17]. These findings reveal a rich and underexplored conformational landscape that governs GPCR signaling. In addition, native membrane components—such as lipids and interacting proteins, including GPCR oligomers—are known to significantly modulate receptor function [11, 18-22].<br>\r\nTo disentangle these intricacies, computational modeling has become indispensable, offering atomistic insight into GPCR conformational dynamics and mechanistic understanding [1-2, 7, 11, 14, 16–21, 23]. Nevertheless, key questions remain - particularly regarding the structural basis of biased signaling, strategies for leveraging allosteric networks in pharmacology, and the modulatory role of the lipid environment. Addressing these gaps is crucial for both fundamental biology and the rational design of next-generation GPCR-targeting drugs with improved selectivity and safety profiles. <br>\r\nThese scientific challenges form the foundation of our upcoming workshop, which will focus on the latest experimental and computational approaches for studying the functional dynamics of GPCRs. Given the profound health, economic, and societal implications of modulating these receptors with precision, we aim to strengthen the interdisciplinary nature of the event by increasing the representation of experimental research and integrating cutting-edge artificial intelligence applications into the program.<br>\r\nBuilding upon the success of the 2022 and 2024 editions - which led to new collaborations and a landmark publication in <em>Nature Reviews Drug Discovery</em> [24] - our goal is to further enhance communication and collaboration between experimentalists and theoreticians. The workshop will serve as a reference point for young scientists and students, offering a platform to interact with leading international experts. We are confident that this initiative will foster insightful discussions and contribute meaningfully to advancing the field of GPCR pharmacology.<br>\r\n<br>\r\n<strong>References</strong><br>\r\n<br>\r\n<a href=\"https://doi.org/10.1038/nrd.2017.229\" target=\"_blank\">[1] J. Smith, R. Lefkowitz, S. Rajagopal, Nat. Rev. Drug. Discov., <strong>17</strong>, 243-260 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41573-024-01083-3\" target=\"_blank\">[2] P. Conflitti, E. Lyman, M. Sansom, P. Hildebrand, H. Gutiérrez-de-Terán, P. Carloni, T. Ansell, S. Yuan, P. Barth, A. Robinson, C. Tate, D. Gloriam, S. Grzesiek, M. Eddy, S. Prosser, V. Limongelli, Nat. Rev. Drug. Discov., <strong>24</strong>, 251-275 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41589-024-01682-6\" target=\"_blank\">[3] L. Picard, A. Orazietti, D. Tran, A. Tucs, S. Hagimoto, Z. Qi, S. Huang, K. Tsuda, A. Kitao, A. Sljoka, R. Prosser, Nat. Chem. Biol., <strong>21</strong>, 71-79 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.drudis.2020.10.006\" target=\"_blank\">[4] B. Huang, C. St. Onge, H. Ma, Y. Zhang, Drug Discovery Today, <strong>26</strong>, 189-199 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-023-42082-z\" target=\"_blank\">[5] D. Di Marino, P. Conflitti, S. Motta, V. Limongelli, Nat. Commun., <strong>14</strong>, 6439 (2023)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.ceb.2018.10.007\" target=\"_blank\">[6] G. Milligan, R. Ward, S. Marsango, Current Opinion in Cell Biology, <strong>57</strong>, 40-47 (2019)</a><br>\r\n<a href=\"https://doi.org/10.7554/elife.73901\" target=\"_blank\">[7] S. Huang, O. Almurad, R. Pejana, Z. Morrison, A. Pandey, L. Picard, M. Nitz, A. Sljoka, R. Prosser, eLife, <strong>11</strong>, (2022)</a><br>\r\n<a href=\"https://doi.org/10.1146/annurev-pharmtox-010919-023411\" target=\"_blank\">[8] A. Duncan, W. Song, M. Sansom, Annu. Rev. Pharmacol. Toxicol., <strong>60</strong>, 31-50 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-025-60003-0\" target=\"_blank\">[9] A. Morales-Pastor, T. Miljuš, M. Dieguez-Eceolaza, T. Stępniewski, V. Ledesma-Martin, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, D. Sykes, C. Nicholson, E. Koers, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent, Nat. Commun., <strong>16</strong>, 5265 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-022-05588-y\" target=\"_blank\">[10] A. Faouzi, H. Wang, S. Zaidi, J. DiBerto, T. Che, Q. Qu, M. Robertson, M. Madasu, A. El Daibani, B. Varga, T. Zhang, C. Ruiz, S. Liu, J. Xu, K. Appourchaux, S. Slocum, S. Eans, M. Cameron, R. Al-Hasani, Y. Pan, B. Roth, J. McLaughlin, G. Skiniotis, V. Katritch, B. Kobilka, S. Majumdar, Nature, <strong>613</strong>, 767-774 (2022)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-022-31652-2\" target=\"_blank\">[11] M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, E. Dean, C. Hume, S. Hayward, J. Oliver, F. Zhao, D. Spanswick, C. Reynolds, M. Lochner, G. Ladds, B. Frenguelli, Nat. Commun., <strong>13</strong>, 4150 (2022)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41580-018-0049-3\" target=\"_blank\">[12] D. Wootten, A. Christopoulos, M. Marti-Solano, M. Babu, P. Sexton, Nat. Rev. Mol. Cell. Biol., <strong>19</strong>, 638-653 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41594-017-0011-7\" target=\"_blank\">[13] D. Hilger, M. Masureel, B. Kobilka, Nat. Struct. Mol. Biol., <strong>25</strong>, 4-12 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41467-025-57034-y\" target=\"_blank\">[14] D. Aranda-García, T. Stepniewski, M. Torrens-Fontanals, A. García-Recio, M. Lopez-Balastegui, B. Medel-Lacruz, A. Morales-Pastor, A. Peralta-García, M. Dieguez-Eceolaza, D. Sotillo-Nuñez, T. Ding, M. Drabek, C. Jacquemard, J. Jakowiecki, W. Jespers, M. Jiménez-Rosés, V. Jun-Yu-Lim, A. Nicoli, U. Orzel, A. Shahraki, J. Tiemann, V. Ledesma-Martin, F. Nerín-Fonz, S. Suárez-Dou, O. Canal, G. Pándy-Szekeres, J. Mao, D. Gloriam, E. Kellenberger, D. Latek, R. Guixà-González, H. Gutiérrez-de-Terán, I. Tikhonova, P. Hildebrand, M. Filizola, M. Babu, A. Di Pizio, S. Filipek, P. Kolb, A. Cordomi, T. Giorgino, M. Marti-Solano, J. Selent, Nat. Commun., <strong>16</strong>, 2020 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41586-018-0259-z\" target=\"_blank\">[15] D. Thal, A. Glukhova, P. Sexton, A. Christopoulos, Nature, <strong>559</strong>, 45-53 (2018)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.tips.2020.12.005\" target=\"_blank\">[16] L. Slosky, M. Caron, L. Barak, Trends in Pharmacological Sciences, <strong>42</strong>, 283-299 (2021)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.apsb.2023.07.020\" target=\"_blank\">[17] C. Zhu, X. Lan, Z. Wei, J. Yu, J. Zhang, Acta Pharmaceutica Sinica B, <strong>14</strong>, 67-86 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.chempr.2024.08.004\" target=\"_blank\">[18] V. D’Amore, P. Conflitti, L. Marinelli, V. Limongelli, Chem, <strong>10</strong>, 3678-3698 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41557-023-01238-6\" target=\"_blank\">[19] A. Mafi, S. Kim, W. Goddard, Nat. Chem., <strong>15</strong>, 1127-1137 (2023)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41594-024-01334-2\" target=\"_blank\">[20] H. Batebi, G. Pérez-Hernández, S. Rahman, B. Lan, A. Kamprad, M. Shi, D. Speck, J. Tiemann, R. Guixà-González, F. Reinhardt, P. Stadler, M. Papasergi-Scott, G. Skiniotis, P. Scheerer, B. Kobilka, J. Mathiesen, X. Liu, P. Hildebrand, Nat. Struct. Mol. Biol., <strong>31</strong>, 1692-1701 (2024)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.cell.2015.04.043\" target=\"_blank\">[21] A. Manglik, T. Kim, M. Masureel, C. Altenbach, Z. Yang, D. Hilger, M. Lerch, T. Kobilka, F. Thian, W. Hubbell, R. Prosser, B. Kobilka, Cell, <strong>161</strong>, 1101-1111 (2015)</a><br>\r\n<a href=\"https://doi.org/10.1016/j.cell.2020.03.003\" target=\"_blank\">[22] M. Congreve, C. de Graaf, N. Swain, C. Tate, Cell, <strong>181</strong>, 81-91 (2020)</a><br>\r\n<a href=\"https://doi.org/10.1038/s41573-025-01139-y\" target=\"_blank\">[23] J. Lorente, A. Sokolov, G. Ferguson, H. Schiöth, A. Hauser, D. Gloriam, Nat. Rev. Drug. Discov., <strong>24</strong>, 458-479 (2025)</a><br>\r\n<a href=\"https://doi.org/10.1111/bph.16495\" target=\"_blank\">[24] M. Lopez‐Balastegui, T. Stepniewski, M. Kogut‐Günthel, A. Di Pizio, M. Rosenkilde, J. Mao, J. Selent, British. J. Pharmacology., <strong>182</strong>, 3211-3224 (2024)</a>\r\n</p><div class=\"active tab-pane\"> </div>", "image_description": "", "creation_date": "2026-01-26T16:00:31", "last_modification_date": "2026-01-26T16:45:08", "link_label": "G protein-coupled receptors functional dynamics revealed by experimental and computational structura", "link_url": "https://www.cecam.org/workshop-details/g-protein-coupled-receptors-functional-dynamics-revealed-by-experimental-and-computational-structural-data-1488", "canceled": "False", "cancel_reason": "", "place_and_room": "Aula Magna, USI Lugano", "url_place_and_room": "https://www.desk.usi.ch/en/lugano-campus-map-access-facilities", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "", "organizer": "<strong>Vittorio Limongelli</strong>, Università della Svizzera Italiana USI Lugano ; <strong>Scott Prosser</strong>, University of Toronto ; <strong>Stefano Raniolo</strong>, Università della Svizzera Italiana ; <strong>Jana Selent</strong>, Hospital Del Mar Medical Research Institute", "contact": "<a href=\"mailto:[email protected]\"><strong>Cornelia Bujenita</strong></a>, CECAM Events and Operations Manager", "is_internal": "False", "theme": "", "vulgarization": { "id": 2, "fr_label": "Public averti", "en_label": "Informed public" }, "registration": { "id": 1, "fr_label": "Sur inscription", "en_label": "Registration required" }, "keywords": "", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119453/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/1/?format=api", "https://memento.epfl.ch/api/v1/mementos/5/?format=api", "https://memento.epfl.ch/api/v1/mementos/6/?format=api", "https://memento.epfl.ch/api/v1/mementos/8/?format=api", "https://memento.epfl.ch/api/v1/mementos/27/?format=api" ] }, { "id": 70935, "title": "Genome-wide in vitro reconstitution to study nucleosome positioning and chromatin architecture", "slug": "genome-wide-in-vitro-reconstitution-to-study-nucle", "event_url": "https://memento.epfl.ch/event/genome-wide-in-vitro-reconstitution-to-study-nucle", "visual_url": "https://memento.epfl.ch/image/32323/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32323/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32323/max-size.jpg", "lang": "en", "start_date": "2026-05-20", "end_date": "2026-05-20", "start_time": "17:00:00", "end_time": "18:30:00", "description": "<p>Access to genetic information within the cell nucleus is regulated by the distribution of nucleosomes, which are the basic unit of chromatin. Local access to specific genomic regions is facilitated by repositioning nucleosomes to enable transcription and other nuclear processes. Nucleosome positioning is primarily regulated by ATP-dependent chromatin remodeling enzymes (CRs) that belong to the Snf2-type helicase family. These enzymes disrupt histone-DNA contacts by consuming ATP. The functions of CRs can be redundant or essential, complicating their study in vivo. To address this, we employ a unique bottom-up approach, in which we reconstitute chromatin in vitro using purified proteins and a yeast genomic plasmid library. To elucidate the diverse remodeling functions of CRs, we add purified CRs in combination with various transcription factors to the in vitro reconstituted chromatin. The resulting changes in nucleosome positioning are monitored using MNase-seq. Depending on the type of CR used, we observe distinct nucleosome positioning patterns. Furthermore, we have expanded our in vitro reconstitution approach to explore the 3D genome organization of reconstituted chromatin, discovering a role for CRs in the 3D genome organization of <em>S. cerevisiae</em>.</p>", "image_description": "", "creation_date": "2026-01-23T09:41:37", "last_modification_date": "2026-03-10T12:18:20", "link_label": "", "link_url": "", "canceled": "False", "cancel_reason": "", "place_and_room": "BCH 2218", "url_place_and_room": "https://plan.epfl.ch/?room==BCH%202218", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "<a href=\"https://www.uni-goettingen.de/en/689675.html\">Elisa Oberbeckmann</a> (University of Goettingen)", "organizer": "Professeur Beat Fierz", "contact": "Marie Munoz", "is_internal": "False", "theme": "", "vulgarization": { "id": 2, "fr_label": "Public averti", "en_label": "Informed public" }, "registration": { "id": 3, "fr_label": "Entrée libre", "en_label": "Free" }, "keywords": "CBseminar", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119413/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/1/?format=api", "https://memento.epfl.ch/api/v1/mementos/14/?format=api", "https://memento.epfl.ch/api/v1/mementos/6/?format=api" ] }, { "id": 71507, "title": "Genome-wide mapping of Transcription Factors' Footprints: Probing Noncoding Variants of Human Diseases", "slug": "genome-wide-mapping-of-transcription-factors-footp", "event_url": "https://memento.epfl.ch/event/genome-wide-mapping-of-transcription-factors-footp", "visual_url": null, "visual_large_url": null, "visual_maxsize_url": null, "lang": "en", "start_date": "2026-05-08", "end_date": "2026-05-08", "start_time": "15:00:00", "end_time": "16:00:00", "description": "", "image_description": "", "creation_date": "2026-03-31T15:22:33", "last_modification_date": "2026-03-31T15:22:33", "link_label": "", "link_url": "", "canceled": "False", "cancel_reason": "", "place_and_room": "SV 1717", "url_place_and_room": "https://plan.epfl.ch/?room==SV%201717", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "<strong>Professor Xiaoliang Sunney Xie</strong><br>\r\nDirector of Changping Laboratory, Beijing, China<br>\r\nLee Shau Kee Chair Professor, Peking University, Haidian District, Beijing, China<br>\r\nhttps://www.cpl.ac.cn/en/Directors_Message/index.html ", "organizer": "Pr. Johan Auwerx", "contact": "Pr. Johan Auwerx: [email protected]", "is_internal": "False", "theme": "", "vulgarization": { "id": 2, "fr_label": "Public averti", "en_label": "Informed public" }, "registration": { "id": 3, "fr_label": "Entrée libre", "en_label": "Free" }, "keywords": "", "file": "https://memento.epfl.ch/public/upload/files/SEMSunneyXie0526LISP.pdf", "icalendar_url": "https://memento.epfl.ch/event/export/120252/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/8/?format=api", "https://memento.epfl.ch/api/v1/mementos/9/?format=api", "https://memento.epfl.ch/api/v1/mementos/111/?format=api" ] }, { "id": 71000, "title": "Gestion de projet européen - Projets collaboratifs", "slug": "gestion-de-projet-europeen-projets-collaboratifs-2", "event_url": "https://memento.epfl.ch/event/gestion-de-projet-europeen-projets-collaboratifs-2", "visual_url": "https://memento.epfl.ch/image/32388/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32388/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32388/max-size.jpg", "lang": "en", "start_date": "2026-09-01", "end_date": "2026-09-01", "start_time": "09:30:00", "end_time": "12:00:00", "description": "<p>Programmes-cadres européens de la recherche et de l’innovation.<br>\r\n<br>\r\nVotre laboratoire participe à un ou plusieurs projets européens et une de vos missions est d’en assurer une gestion efficace au niveaux administratif, financier et celui des ressources humaines ? Pour cela, il est important de prendre le temps de vous familiariser avec la structure de ces projets et avec certaines règles de gestion qui leurs sont spécifiques.<br>\r\n<br>\r\nCette formation vous propose de prendre connaissance des documents contractuels et de leur contenu qui est utile pour votre gestion. Les règles de gestion administrative, financière et RH seront présentées et discutées en se basant sur des cas pratiques.<br>\r\nLa formation permettra aussi aux participants de se familiariser avec le portail européen et la plateforme de reporting du SEFRI.<br>\r\n<br>\r\nIl est recommandé de suivre cette formation le plus tôt possible, idéalement vers le commencement du projet.</p>", "image_description": "", "creation_date": "2026-01-30T10:08:17", "last_modification_date": "2026-01-30T10:10:37", "link_label": "Inscription", "link_url": "https://epfl.eu.crossknowledge.com/site/m/public_training/565", "canceled": "False", "cancel_reason": "", "place_and_room": "", "url_place_and_room": "", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/1/?format=api" ], "speaker": "EU-Funding Team of the Research Office", "organizer": "KeepLearning", "contact": "[email protected]", "is_internal": "True", "theme": "", "vulgarization": { "id": 1, "fr_label": "Tout public", "en_label": "General public" }, "registration": { "id": 1, "fr_label": "Sur inscription", "en_label": "Registration required" }, "keywords": "", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119523/", "category": { "id": 15, "code": "FORM", "fr_label": "Formations internes", "en_label": "Internal trainings", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/145/?format=api", "https://memento.epfl.ch/api/v1/mementos/431/?format=api", "https://memento.epfl.ch/api/v1/mementos/6/?format=api" ] }, { "id": 71001, "title": "Gestion de projet européen - Projets ERC et MSCA", "slug": "gestion-de-projet-europeen-projets-erc-et-msca-2", "event_url": "https://memento.epfl.ch/event/gestion-de-projet-europeen-projets-erc-et-msca-2", "visual_url": "https://memento.epfl.ch/image/32389/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32389/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32389/max-size.jpg", "lang": "en", "start_date": "2026-11-26", "end_date": "2026-11-26", "start_time": "09:30:00", "end_time": "12:00:00", "description": "<p>Programmes-cadres européens de la recherche et de l’innovation.<br>\r\n<br>\r\nVotre laboratoire participe à un ou plusieurs projets européens et une de vos missions est d’en assurer une gestion efficace au niveaux administratif, financier et celui des ressources humaines ? Pour cela, il est important de prendre le temps de vous familiariser avec la structure de ces projets et avec certaines règles de gestion qui leurs sont spécifiques.<br>\r\n<br>\r\nCette formation vous propose de prendre connaissance des documents contractuels et de leur contenu qui est utile pour votre gestion. Les règles de gestion administrative, financière et RH seront présentées et discutées en se basant sur des cas pratiques.<br>\r\nLa formation permettra aussi aux participants de se familiariser avec le portail européen et la plateforme de reporting du SEFRI.<br>\r\n<br>\r\nIl est recommandé de suivre cette formation le plus tôt possible, idéalement vers le commencement du projet.</p>", "image_description": "", "creation_date": "2026-01-30T10:11:14", "last_modification_date": "2026-01-30T10:12:40", "link_label": "Inscription", "link_url": "https://epfl.eu.crossknowledge.com/site/m/public_training/565", "canceled": "False", "cancel_reason": "", "place_and_room": "", "url_place_and_room": "", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/1/?format=api" ], "speaker": "EU-Funding Team of the Research Office", "organizer": "KeepLearning", "contact": "[email protected]", "is_internal": "True", "theme": "", "vulgarization": { "id": 1, "fr_label": "Tout public", "en_label": "General public" }, "registration": { "id": 1, "fr_label": "Sur inscription", "en_label": "Registration required" }, "keywords": "", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119525/", "category": { "id": 15, "code": "FORM", "fr_label": "Formations internes", "en_label": "Internal trainings", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/145/?format=api", "https://memento.epfl.ch/api/v1/mementos/431/?format=api", "https://memento.epfl.ch/api/v1/mementos/6/?format=api" ] }, { "id": 71068, "title": "Herzog & .... Labs", "slug": "herzog-labs", "event_url": "https://memento.epfl.ch/event/herzog-labs", "visual_url": "https://memento.epfl.ch/image/32446/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32446/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32446/max-size.jpg", "lang": "en", "start_date": "2026-04-29", "end_date": "2026-04-29", "start_time": "12:15:00", "end_time": "13:15:00", "description": "<em>Hybrid - By invitation only</em><br>\r\n<br>\r\nHerzog Lab: Martina Morea<br>\r\n<br>\r\nTitle: Seeing Comes After Grouping: How the Brain Builds Visual Perception<br>\r\n<br>\r\n<br>\r\n ", "image_description": "", "creation_date": "2026-02-09T02:24:48", "last_modification_date": "2026-02-20T12:57:33", "link_label": "", "link_url": "", "canceled": "False", "cancel_reason": "", "place_and_room": "SV 1717", "url_place_and_room": "https://plan.epfl.ch/?room==SV%201717", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "Martina Morea", "organizer": "SV BMI", "contact": "[email protected]", "is_internal": "False", "theme": "", "vulgarization": { "id": 1, "fr_label": "Tout public", "en_label": "General public" }, "registration": { "id": 3, "fr_label": "Entrée libre", "en_label": "Free" }, "keywords": "", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119615/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/19/?format=api" ] }, { "id": 71015, "title": "HFSP | 2027 Postdoctoral Fellowships", "slug": "hfsp-2027-postdoctoral-fellowships", "event_url": "https://memento.epfl.ch/event/hfsp-2027-postdoctoral-fellowships", "visual_url": "https://memento.epfl.ch/image/32401/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/32401/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/32401/max-size.jpg", "lang": "en", "start_date": "2026-05-05", "end_date": "2026-05-05", "start_time": null, "end_time": null, "description": "<strong>Aim: </strong> The HFSP fellowship program supports proposals for frontier, potentially transformative research in the <strong>life sciences</strong>. Applications for <strong>high-risk</strong> projects are particularly encouraged. The projects should be <strong>interdisciplinary</strong> in nature and should challenge existing paradigms by using novel approaches and techniques. Scientifically, they should address an important problem or a barrier to progress in the field.<br>\r\n<br>\r\nHFSP postdoctoral fellowships encourage early career scientists to broaden their research skills by moving into new areas of study while working in a new country.<br>\r\n<br>\r\nTwo different fellowships are available:<br>\r\n \r\n<ul>\r\n\t<li><strong>Long-Term Fellowships (LTF) </strong>are for applicants with a PhD on a biological topic who want to embark on a novel and frontier project focusing on the life sciences.</li>\r\n\t<li><strong>Cross-Disciplinary Fellowships (CDF)</strong> are for applicants who hold a doctoral degree from a non-biological discipline (e.g. physics, chemistry, mathematics, engineering or computer sciences) and who have not worked in the life sciences before.</li>\r\n</ul>\r\n<br>\r\n<strong>Funding</strong>: Living allowance according to host country (see <a href=\"https://www.hfsp.org/sites/default/files/Sciences/fellows/2027/HFSP%20Fellowships%202027%20-%20Application%20Guidelines.pdf\">Guidelines</a>), as well as a research and travel allowance.<br>\r\n<br>\r\n<strong>Duration</strong>: 36 months<br>\r\n<br>\r\n<strong>Eligibility:</strong> A summary of eligibility criteria is given below. For full details, please see the <a href=\"https://www.hfsp.org/sites/default/files/Sciences/fellows/2027/HFSP%20Fellowships%202027%20-%20Application%20Guidelines.pdf\">Guidelines</a>.<br>\r\n \r\n<ul>\r\n\t<li><strong>Anyone from any country and any nationality can apply for a fellowship</strong>. However, candidates <u>cannot</u> apply for a fellowship to work in the country of their nationality, regardless of whether they have obtained their PhD degree in this or another country. Further, A candidate who is not a national of one of the HFSPO members (see page 5 of the Guidelines) may apply to work only in a research institution in one of the member countries. A candidate who is a national of one of the member countries can apply to work in a research institution in any country that they are not a national of.</li>\r\n\t<li><strong>Applicants must propose to work in a country different from the one where they did their previous PhD work or first post-doctoral studies.</strong> For those institutions that are not classified as national, i.e. international or extraterritorial institutions such as EMBL, ICPT or ICGEB, the country in which the laboratory is located will be considered the host country. Candidates should not have spent more than 12 months in their proposed host institution at the activation date of the fellowship.</li>\r\n\t<li><strong>A research doctorate (PhD)</strong> or a doctoral-level degree comparable to a PhD with equivalent experience in basic research (e.g. a research based MD or medical PhD) must be conferred by the start of the fellowship, but is not required at the time of submission. If PhD has already been awarded, The degree must have been conferred in the 3 years prior to the submission deadline</li>\r\n\t<li><strong>Applicants must propose a research topic different to that of their PhD</strong> <strong>and previous postdoctoral work.</strong> The proposal must align with the mission and objectives of HFSP and the scientific scope of the HFSP Fellowship program.</li>\r\n\t<li><strong>Applicants must have at least one full-length original research publication, </strong>in English, for which the applicant is a lead author (e.g. applicant is either the single author, first author, or joint-first author)<strong>.</strong> By the submission deadline of the Letter of Intent, the manuscript should be either i) already published, (ii) accepted and in press, or (iii) accepted for publication in a peer-reviewed journal, or (iv) available online in a recognized open-access (OA) preprint repository AND submitted to a peer-reviewed journal.</li>\r\n</ul>\r\n<br>\r\n<strong>How to Apply</strong>: <strong>Applications</strong> will follow a two-step submission process via the online submission platform <a href=\"https://proposalcentral.com/\"><strong>ProposalCentral</strong></a>. First, applicants will be asked to initiate a Letter of Intent by 5 May 2026; full instructions for the LoI submission can be found <a href=\"https://www.hfsp.org/sites/default/files/Sciences/fellows/2027/HFSP%20Fellowships%202027%20-%20PC%20instructions%20for%20LOI%20applicants_0.pdf\">here</a>.<br>\r\n<br>\r\nIn a second step, successful applicants (~15-20%) will be invited to submit a Full Application. If invited, full proposals must be submitted by 24 September 2026. Please note that the signing official of the host institution must sign off on the full proposal submission on ProposalCentral; please leave plenty of time for this step. If EPFL will be your host institution, please contact the <a href=\"mailto:[email protected]\">Research Office</a> for any questions on the institutional signoff.<br>\r\n<br>\r\n<strong>Deadline, LOI initiation:</strong> 5 May 2026<br>\r\n<br>\r\n<strong>Further information</strong>\r\n\r\n<ul>\r\n\t<li>More information about the program is available <a href=\"https://www.hfsp.org/funding/hfsp-funding/postdoctoral-fellowships\">here</a></li>\r\n\t<li>The application portal can be found <a href=\"https://proposalcentral.com/\">here</a></li>\r\n\t<li>For any other questions, please contact the <a href=\"mailto:[email protected]\">Research Office</a></li>\r\n</ul>", "image_description": "", "creation_date": "2026-02-02T15:29:45", "last_modification_date": "2026-02-02T17:12:31", "link_label": "", "link_url": "", "canceled": "False", "cancel_reason": "", "place_and_room": "", "url_place_and_room": "", "url_online_room": "", "spoken_languages": [], "speaker": "", "organizer": "", "contact": "<a href=\"mailto:[email protected]?subject=HFSP%20Fellowhsips\">Research Office</a>", "is_internal": "False", "theme": "", "vulgarization": { "id": 1, "fr_label": "Tout public", "en_label": "General public" }, "registration": { "id": 3, "fr_label": "Entrée libre", "en_label": "Free" }, "keywords": "", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/119546/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/140/?format=api" ] }, { "id": 69803, "title": "Higher moments for the SHE in high dimensions and their phase transitions", "slug": "higher-moments-for-the-she-in-high-dimensions-and", "event_url": "https://memento.epfl.ch/event/higher-moments-for-the-she-in-high-dimensions-and", "visual_url": "https://memento.epfl.ch/image/31288/200x112.jpg", "visual_large_url": "https://memento.epfl.ch/image/31288/720x405.jpg", "visual_maxsize_url": "https://memento.epfl.ch/image/31288/max-size.jpg", "lang": "en", "start_date": "2026-04-14", "end_date": "2026-04-15", "start_time": "10:10:00", "end_time": "11:00:00", "description": "<p>We consider regularized versions of the stochastic heat equation (SHE) in high dimensions $d\\geq 3$ and analyze their higher moments in the limit as the regularization is removed, for varying coupling constants that describe the strength of the driving noise. Motivated by recent results on the higher moments of the SHE in two dimensions at $L^{2}$-criticality, a natural question is whether the higher moments of the SHE in high dimensions also converge at the $L^{2}$-critical point. Our main result gives a negative answer: in high dimensions, the higher moments diverge when the coupling constant belongs to a nontrivial right-closed interval whose upper endpoint is the $L^{2}$-critical point. In particular, we obtain a sharp bound for the critical coupling constant at which the corresponding limiting higher moment undergoes a phase transition. As an application to the continuous directed polymer, we derive a sharp estimate for quantity believed to be closely related to the tail probability of the limiting partition function.</p>", "image_description": "", "creation_date": "2025-09-12T13:47:07", "last_modification_date": "2026-03-30T15:59:29", "link_label": "Working-Reading Seminar", "link_url": "https://www.epfl.ch/labs/stoan/reading-working-seminar/", "canceled": "False", "cancel_reason": "", "place_and_room": "MA B2 485", "url_place_and_room": "", "url_online_room": "", "spoken_languages": [ "https://memento.epfl.ch/api/v1/spoken_languages/2/?format=api" ], "speaker": "Dr Te-Chun Wang (EPFL)", "organizer": " <a href=\"https://people.epfl.ch/xue-mei.li\">Xue-Mei Li</a>", "contact": "<a href=\"https://people.epfl.ch/xue-mei.li\">Xue-Mei Li</a>", "is_internal": "False", "theme": "", "vulgarization": { "id": 3, "fr_label": "Expert", "en_label": "Expert" }, "registration": { "id": 3, "fr_label": "Entrée libre", "en_label": "Free" }, "keywords": "Reading-Working Seminar", "file": null, "icalendar_url": "https://memento.epfl.ch/event/export/117635/", "category": { "id": 1, "code": "CONF", "fr_label": "Conférences - Séminaires", "en_label": "Conferences - Seminars", "activated": true }, "academic_calendar_category": null, "domains": [], "mementos": [ "https://memento.epfl.ch/api/v1/mementos/403/?format=api", "https://memento.epfl.ch/api/v1/mementos/7/?format=api" ] } ] }
