'Thiol-based Redox Signaling'
PD Dr. Tobias P. Dick, at the German Cancer Research Center (DKFZ), Heidelberg, develops tools for the visualization and manipulation of redox processes in vivo. He uses these tools to investigate adaptive stress responses in normal and tumor cells.
About the talk
Redox signaling is a process by which endogenous oxidants, derived from metabolism, reversibly modify particular thiols on particular proteins to change their functional behavior in an adaptive manner. However, the molecular mechanisms of redox signaling remain largely unknown. In many cases, specificity and efficiency of redox signaling remain unexplained. An emerging solution to this conundrum is that redox signaling can be mediated and channeled by protein-to-protein redox relay chains. There is growing evidence that H2O2 signals are relayed through thiol peroxidases to neighboring proteins within supramolecular assemblies.
About the speaker
Tobias Dick studied Biochemistry at the Free University of Berlin and obtained a PhD in Molecular Immunology working with Hans-Georg Rammensee at the University of Tübingen. He was a Postdoctoral Fellow with Peter Cresswell at Yale University and then continued as an independent group leader in the field of Redox Biology at the German Cancer Research Center (DKFZ) in Heidelberg. In 2010, he was appointed Head of the Division of Redox Biology at DKFZ. Tobias Dick works on the molecular mechanisms of redox signaling and protein redox regulation. He develops tools for the visualization and manipulation of redox processes in vivo. He uses these tools to investigate adaptive stress responses in normal and tumor cells.
The talk will take place via Zoom (link will be sent to registered participants, a few days before the event)
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Deadline to register : October 8, 2020
- Registration required
- NCCR Chemical Biology