A Silicon-Based Platform for Biochemical Sensing
Event details
| Date | 26.06.2018 |
| Hour | 13:30 › 14:30 |
| Speaker | Mathias Wipf, Ph.D., EMPA, Dübendorf (CH) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Potentiometric sensors based on ion-sensitive field-effect transistors have attracted a lot of interest due to their potential to be integrated in sensor systems for the analysis of multiple biochemical parameters at low dimensions and cost. The specific sensing of ions and proteins over large concentration ranges has been reported using various detection schemes. However, the commercial success of micro- and nanoscale potentiometric sensors has not exceeded pH measurements. We studied the intrinsic limitations of this technology, such as signal-to-noise ratio, Debye screening, and competing surface reactions, and present methods how to address these. We have studied the label-free detection of various metal ions, such as Na+, Ca2+ and Cu2+, and proteins using silicon nanowire field-effect transistors. Further, we have demonstrated methods to quantify proteins in blood and serum at high specificity using enzyme-linked immunosorbent assays in combination with an electrical readout. Currently we are working on the commercialization of solid-state potentiometric sensors for the use in point-of-care diagnostics.
Bio:
Mathias Wipf obtained his Master degree in nanoscience at the University of Basel, where he completed his Ph.D. in physics in Prof. Christian Schönenberger’s group, studying biosensors based on silicon nanowires for the detection of ions and proteins. Afterwards he accepted a research position as postdoc in Prof. Mark Reed’s group at the department of electrical engineering at Yale University, where he worked on electrical readout methods of immunoassays. In 2016, he joined the Silicon Valley startup Avails Medical, Inc., where he is working on the development of an in vitro diagnostic test for the detection of bacterial infections, which allows the quantification of bacteria and antibiotic susceptibility testing in blood samples. He recently founded the company MOMM Diagnostics GmbH in Basel, for the development of a point-of-care test for preeclampsia, one of the most common pregnancy complications. In a research collaboration with Prof. Michel Calame at EMPA, Switzerland, he is currently leading the biosensor team in the laboratory “Transport at nanoscale interfaces”, working on new methods for label-free chemical- and biochemical sensing.
Abstract:
Potentiometric sensors based on ion-sensitive field-effect transistors have attracted a lot of interest due to their potential to be integrated in sensor systems for the analysis of multiple biochemical parameters at low dimensions and cost. The specific sensing of ions and proteins over large concentration ranges has been reported using various detection schemes. However, the commercial success of micro- and nanoscale potentiometric sensors has not exceeded pH measurements. We studied the intrinsic limitations of this technology, such as signal-to-noise ratio, Debye screening, and competing surface reactions, and present methods how to address these. We have studied the label-free detection of various metal ions, such as Na+, Ca2+ and Cu2+, and proteins using silicon nanowire field-effect transistors. Further, we have demonstrated methods to quantify proteins in blood and serum at high specificity using enzyme-linked immunosorbent assays in combination with an electrical readout. Currently we are working on the commercialization of solid-state potentiometric sensors for the use in point-of-care diagnostics.
Bio:
Mathias Wipf obtained his Master degree in nanoscience at the University of Basel, where he completed his Ph.D. in physics in Prof. Christian Schönenberger’s group, studying biosensors based on silicon nanowires for the detection of ions and proteins. Afterwards he accepted a research position as postdoc in Prof. Mark Reed’s group at the department of electrical engineering at Yale University, where he worked on electrical readout methods of immunoassays. In 2016, he joined the Silicon Valley startup Avails Medical, Inc., where he is working on the development of an in vitro diagnostic test for the detection of bacterial infections, which allows the quantification of bacteria and antibiotic susceptibility testing in blood samples. He recently founded the company MOMM Diagnostics GmbH in Basel, for the development of a point-of-care test for preeclampsia, one of the most common pregnancy complications. In a research collaboration with Prof. Michel Calame at EMPA, Switzerland, he is currently leading the biosensor team in the laboratory “Transport at nanoscale interfaces”, working on new methods for label-free chemical- and biochemical sensing.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)