A Tale of Two Cytokines - Embryonic Stem Cell Self Renewal and its Relationship to Lineage Specification
Event details
| Date | 15.09.2014 |
| Hour | 12:15 |
| Speaker | Prof. Joshua M. Brickman, The Danish Stem Cell Centre (DanStem), University of Copenhagen (DK) |
| Location | |
| Category | Conferences - Seminars |
DISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING
Abstract:
Recent observations have suggested that Embryonic Stem Cells (ESC) are not a single cell type, but a complex and heterogeneous culture system. Our work suggests that underlying this heterogeneity may be in vitro selection pressure, driving individual ESCs, initially derived from the early mammalian embryo, to attempt to rebuild their own niche. In this context I will also talk about two signaling pathways canonically associated with ESC self-renewal and pluripotency, Fgf and Lif, and discuss how they regulate heterogeneity and potency.
Bio:
Ph.D. (Biochemistry and Molecular Biology), Harvard University (1996)
B.A. (Chemistry & Philosophy), University of Vermont (1985)
Josh Brickman has a background in molecular biology and gene regulation. From a PhD in transcription he trained in developmental biology as a post-doctoral fellow, working in early mouse, and Xenopus, as well as cultivating embryonic stem cells as a model for developmental biology. He began his own lab with research projects bridging early development in multiple models systems with ES cells in a hybrid approach aimed at understanding conserved mechanisms of pluripotency and self renewal.
He currently seeks to understand how transcription factors regulate cell fate choice in ES cells and early embryos. More specifically, Professor Brickman’s and his group investigate the basis for transcriptional priming and commitment in ES cells and early in the specification of the endoderm lineage. They hope to understand the relevance of these priming events to stem and progenitor cell potency.
Abstract:
Recent observations have suggested that Embryonic Stem Cells (ESC) are not a single cell type, but a complex and heterogeneous culture system. Our work suggests that underlying this heterogeneity may be in vitro selection pressure, driving individual ESCs, initially derived from the early mammalian embryo, to attempt to rebuild their own niche. In this context I will also talk about two signaling pathways canonically associated with ESC self-renewal and pluripotency, Fgf and Lif, and discuss how they regulate heterogeneity and potency.
Bio:
Ph.D. (Biochemistry and Molecular Biology), Harvard University (1996)
B.A. (Chemistry & Philosophy), University of Vermont (1985)
Josh Brickman has a background in molecular biology and gene regulation. From a PhD in transcription he trained in developmental biology as a post-doctoral fellow, working in early mouse, and Xenopus, as well as cultivating embryonic stem cells as a model for developmental biology. He began his own lab with research projects bridging early development in multiple models systems with ES cells in a hybrid approach aimed at understanding conserved mechanisms of pluripotency and self renewal.
He currently seeks to understand how transcription factors regulate cell fate choice in ES cells and early embryos. More specifically, Professor Brickman’s and his group investigate the basis for transcriptional priming and commitment in ES cells and early in the specification of the endoderm lineage. They hope to understand the relevance of these priming events to stem and progenitor cell potency.
Practical information
- Informed public
- Free