Adult Stem Cell Control: from Lineage Decisions to Genome Stability
Event details
| Date | 23.09.2016 |
| Hour | 12:15 |
| Speaker | Allison Bardin, Ph.D., Institut Curie, CNRS, Paris (F) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Adult stem cells are long-lived residents in adult tissues acting to replenish terminally differentiated cells. My seminar will explore two important questions of adult stem cell biology using the Drosophila intestinal stem cell model system: how are terminal cell fate decisions controlled and how stable is the genome of adult stem cells? I will present evidence that secretory cell fate specification requires Numb to inhibit Notch activity and I will discuss mechanisms upstream and downstream allowing EE cell fate specification. In a second part, I will present our finding of frequent spontaneous mutations in adult intestinal stem cells and their effects on the adult tissue.
Bio:
Education:
2003: Ph.D., Biology, Massachusetts Institute of Technology, MA (USA)
1997: B.A., Biochemistry, University of California, Berkeley, CA (USA) Research Experience:
September 2010-present: Group Leader of Stem Cell and Tissue Homeostasis team in the Department of Developmental Biology and Cancer.
Institut Curie (CNRS UMR 3215/ Inserm U934) CR1 CNRS, Paris (F)
Investigating novel mechanisms regulating adult stem cells using the Drosophila adult intestine. 2006-August 2010:
Research scientist CR2 CNRS in the lab of Dr. Francois Schweisguth.
Institut Pasteur, CNRS URA 2578 (Ecole Normale Superieure, CNRS UMR 8542 until 2008).
Investigating mechanisms controlling the fate and differentiation potential of adult stem cell in the Drosophila intestine. 2003-2005:
Post-doctoral research fellow in the laboratory of Dr. François Schweisguth.
Ecole Normale Supérieure CNRS UMR 8542, Paris.
Control of Notch signaling by ligand endocytosis in Drosophila. 1999-2003:
Ph.D. student in the laboratory of Pr. Angelika Amon, Center for Cancer Research, Massachusetts Institute of Technology, USA.
Studied mitotic exit of the cell cycle in budding yeast.
Abstract:
Adult stem cells are long-lived residents in adult tissues acting to replenish terminally differentiated cells. My seminar will explore two important questions of adult stem cell biology using the Drosophila intestinal stem cell model system: how are terminal cell fate decisions controlled and how stable is the genome of adult stem cells? I will present evidence that secretory cell fate specification requires Numb to inhibit Notch activity and I will discuss mechanisms upstream and downstream allowing EE cell fate specification. In a second part, I will present our finding of frequent spontaneous mutations in adult intestinal stem cells and their effects on the adult tissue.
Bio:
Education:
2003: Ph.D., Biology, Massachusetts Institute of Technology, MA (USA)
1997: B.A., Biochemistry, University of California, Berkeley, CA (USA) Research Experience:
September 2010-present: Group Leader of Stem Cell and Tissue Homeostasis team in the Department of Developmental Biology and Cancer.
Institut Curie (CNRS UMR 3215/ Inserm U934) CR1 CNRS, Paris (F)
Investigating novel mechanisms regulating adult stem cells using the Drosophila adult intestine. 2006-August 2010:
Research scientist CR2 CNRS in the lab of Dr. Francois Schweisguth.
Institut Pasteur, CNRS URA 2578 (Ecole Normale Superieure, CNRS UMR 8542 until 2008).
Investigating mechanisms controlling the fate and differentiation potential of adult stem cell in the Drosophila intestine. 2003-2005:
Post-doctoral research fellow in the laboratory of Dr. François Schweisguth.
Ecole Normale Supérieure CNRS UMR 8542, Paris.
Control of Notch signaling by ligand endocytosis in Drosophila. 1999-2003:
Ph.D. student in the laboratory of Pr. Angelika Amon, Center for Cancer Research, Massachusetts Institute of Technology, USA.
Studied mitotic exit of the cell cycle in budding yeast.
Practical information
- Informed public
- Free