Advances in Intelligent Hydrogels for Recognitive and Protein Delivery Systems
Event details
| Date | 04.07.2013 |
| Hour | 11:45 › 12:45 |
| Speaker |
Nicholas A. Peppas, Sc.D., The University of Texas, Austin, TX (USA) Bio: Our research contributions have been in several areas of drug delivery, biomaterials, biomolecular engineering, mass transfer, kinetics and reaction engineering, polymers and biomedical engineering. The multidisciplinary approach of thiis research in biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. The fundamental studies of his group have provided valuable results on biomaterials design and development.Our group is known for our work on the preparation, characterization and evaluation of the behavior of compatible, cross linked polymers known as hydrogels, which have been used as biocompatible materials and in controlled release devices, especially in controlled delivery of drugs, peptides and proteins, development of novel biomaterials, biomedical transport phenomena, and biointerfacial problems. Our polymer research has examined fundamental aspects of the thermodynamics of polymer networks in contact with penetrants, the conformational changes of networks under load or in the presence of a diluent, the anomalous transport of penetrants in glassy polymers, and the kinetics of fast UV-polymerization reactions. In the field of controlled release, his group has provided the fundamental basis for a rational development of such systems. In addition, this work has led to a series of novel controlled release systems known as swelling controlled release systems, a series of pH-sensitive devices for drug delivery and a wide range of bio- and mucoadhesive systems. Other biomedical work of his group had dealt with understanding of transport of biological compounds in tissues, analysis of polymer/tissue interactions, and understanding of the behavior of biomembranes. |
| Location | |
| Category | Conferences - Seminars |
DISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING
Engineering the molecular design of intelligent hydrogels by controlling recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. We address design and synthesis characteristics of novel cross-linked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Recent developments in protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition. Molecular imprinting and micro imprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest, can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose- and protein-binding polymers based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media.
Engineering the molecular design of intelligent hydrogels by controlling recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. We address design and synthesis characteristics of novel cross-linked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Recent developments in protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition. Molecular imprinting and micro imprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest, can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose- and protein-binding polymers based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media.
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Practical information
- Informed public
- Free
- This event is internal
Organizer
- Prof. Jeffrey. Hubbell