AMP-activated Protein Kinase: A next generation target for total metabolic control
Event details
| Date | 22.06.2011 |
| Hour | 11:00 |
| Speaker | Dr. Javed IQBAL -Institute of Life Sciences, University of Hyderabad, India |
| Location | |
| Category | Conferences - Seminars |
AMPK is an enzyme that works as a fuel gauge, being activated in conditions of high phosphate depletion. In the liver, activation of AMPK results in decreased production of plasma glucose, cholesterol, triglyceride and enhanced fatty acid oxidation. AMPK is also robustly activated by skeletal muscle contraction and myocardial ischemia, and is involved in the stimulation of glucose transport and fatty acid oxidation by these stimuli. In adipose tissue, activated AMPK inhibits deposition of fat, but enhances breakdown and burning of stored fat, resulting in reduction of body weight. This talk will describe our initial finding demonstrating that AMPK can phosphorylate perilipin to attenuate this protective effect and plays an important role in lipolysis indicating that perilipin is a substrate of AMPK and modulation of AMPK-ACC-Perilipin activities may be a potential useful therapy for metabolic syndrome and obesity.
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