Analysis of tumor microenvironment interactions from an engineering perspective
Event details
| Date | 09.11.2015 |
| Hour | 13:15 › 14:15 |
| Speaker | Prof. Claudia Fischbach-Teschl, Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University |
| Location | |
| Category | Conferences - Seminars |
Microenvironmental conditions contribute to the pathogenesis of cancer, and aberrant extracellular matrix (ECM) remodeling plays a key role in this process. However, our understanding of the specific mechanisms by which the ECM promotes cancer is relatively limited. Our lab focuses on the integration of materials science, tissue engineering, and cancer biology approaches to test the role of ECM biological and physical properties in cancer initiation and progression. More specifically, we characterize the effect of tumors on ECM composition, structure, and mechanics and investigate the relevance of these changes to tumor cell behavior both in vitro and in vivo. Additionally, we are evaluating whether obesity, a condition commonly associated with an increased risk and worse clinical prognosis for cancer, may promote tumorigenesis by mimicking tumor-like ECM dynamics.
Seo BR, DelNero P, Fischbach C, In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer. Advanced Drug Delivery Reviews, 2014 Apr 20;69-70C:205-216.
Chandler, E.M., Seo, Bo Ri, Califano, J.P., Andresen Eguiluz, R.C., Lee, J.S., Yoon, C.J., Tims, D.T., Wang, J.X., Cheng, L., Mohanan, S., Buckley, M.R., Cohen, I., Nikitin, A.Y., Williams, R.M., Gourdon, D., Reinhart-King, C.A., Fischbach, C., Implanted adipose progenitor cells as physicochemical regulators of breast cancer, Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9786-91.
Bio: Claudia Fischbach-Teschl is an Associate Professor of Biomedical Engineering at Cornell University. She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg, Germany, and holds an M.S. in Pharmacy from the Ludwigs-Maximilians-University, Munich, Germany. She conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences and joined the faculty of Cornell in 2007. Her research broadly focuses on utilizing engineering tools and strategies to gain a better understanding of cancer development, progression, and therapy resistance with a particular focus on adipose stroma contributions to breast cancer, bone metastasis and tumor angiogenesis. She has received multiple awards for her work including an AAOS / ORS Molecular Biology and Therapeutics in Musculoskeletal Oncology Young Investigator Award and a Humboldt Research Fellowship for Experienced Researchers from Germany. Furthermore, she is an editorial board member of various journals including the new ACS journal Biomaterials Science and Engineering.
Seo BR, DelNero P, Fischbach C, In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer. Advanced Drug Delivery Reviews, 2014 Apr 20;69-70C:205-216.
Chandler, E.M., Seo, Bo Ri, Califano, J.P., Andresen Eguiluz, R.C., Lee, J.S., Yoon, C.J., Tims, D.T., Wang, J.X., Cheng, L., Mohanan, S., Buckley, M.R., Cohen, I., Nikitin, A.Y., Williams, R.M., Gourdon, D., Reinhart-King, C.A., Fischbach, C., Implanted adipose progenitor cells as physicochemical regulators of breast cancer, Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9786-91.
Bio: Claudia Fischbach-Teschl is an Associate Professor of Biomedical Engineering at Cornell University. She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg, Germany, and holds an M.S. in Pharmacy from the Ludwigs-Maximilians-University, Munich, Germany. She conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences and joined the faculty of Cornell in 2007. Her research broadly focuses on utilizing engineering tools and strategies to gain a better understanding of cancer development, progression, and therapy resistance with a particular focus on adipose stroma contributions to breast cancer, bone metastasis and tumor angiogenesis. She has received multiple awards for her work including an AAOS / ORS Molecular Biology and Therapeutics in Musculoskeletal Oncology Young Investigator Award and a Humboldt Research Fellowship for Experienced Researchers from Germany. Furthermore, she is an editorial board member of various journals including the new ACS journal Biomaterials Science and Engineering.
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Practical information
- General public
- Free
Organizer
- Michele Ceriotti
Contact
- Michele Ceriotti