BioArtificial Hydrogels for Regenerative Medicine
Event details
| Date | 22.08.2016 |
| Hour | 12:15 |
| Speaker | Prof. Andrés J. García, Georgia Institute of Technology, Atlanta, GA, (USA) |
| Location | |
| Category | Conferences - Seminars |
DISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING
(sandwiches served)
Abstract:
Hydrogels, highly hydrated cross-linked polymer networks, have emerged as powerful synthetic analogs of extracellular matrices for basic cell studies as well as promising biomaterials for regenerative medicine applications. A critical advantage of these synthetic matrices over natural networks is that bioactive functionalities, such as cell adhesive sequences and growth factors, can be incorporated in precise densities while the substrate mechanical properties are independently controlled. We have engineered poly(ethylene glycol) [PEG]-maleimide hydrogels to study epithelial morphogenesis and identified independent contributions of biophysical and biochemical properties of these materials to this developmental process. In another application, we have developed synthetic hydrogels that support improved pancreatic islet engraftment, vascularization and function in diabetic models. These studies establish these biofunctional hydrogels as promising platforms for basic science studies and biomaterial carriers for cell delivery, engraftment and enhanced tissue repair.
Bio:
Education
Ph.D., University of Pennsylvania, 1996
M.S.E., University of Pennsylvania, 1992
B.S., Cornell University, 1991
Research Areas and Descriptors:
Bioengineering; Engineered biomaterials and biotherapeutic/cell-delivery vehicles for regenerative medicine applications, including bone repair, vascularization, and inflammation, including arthritis. Mechanisms regulating cell adhesive forces.
(sandwiches served)
Abstract:
Hydrogels, highly hydrated cross-linked polymer networks, have emerged as powerful synthetic analogs of extracellular matrices for basic cell studies as well as promising biomaterials for regenerative medicine applications. A critical advantage of these synthetic matrices over natural networks is that bioactive functionalities, such as cell adhesive sequences and growth factors, can be incorporated in precise densities while the substrate mechanical properties are independently controlled. We have engineered poly(ethylene glycol) [PEG]-maleimide hydrogels to study epithelial morphogenesis and identified independent contributions of biophysical and biochemical properties of these materials to this developmental process. In another application, we have developed synthetic hydrogels that support improved pancreatic islet engraftment, vascularization and function in diabetic models. These studies establish these biofunctional hydrogels as promising platforms for basic science studies and biomaterial carriers for cell delivery, engraftment and enhanced tissue repair.
Bio:
Education
Ph.D., University of Pennsylvania, 1996
M.S.E., University of Pennsylvania, 1992
B.S., Cornell University, 1991
Research Areas and Descriptors:
Bioengineering; Engineered biomaterials and biotherapeutic/cell-delivery vehicles for regenerative medicine applications, including bone repair, vascularization, and inflammation, including arthritis. Mechanisms regulating cell adhesive forces.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Christina Mattsson)