BMI Distinguished Seminar // Connie Cepko: How does the retina make so many cell types?
During development, the retinal progenitor cells must make >120 cell types. Moreover, it makes them in frequencies that vary over 5 orders of magnitude, and distributes each type uniformly so that all areas of the retina can process incoming, local signals. Several lines of evidence suggest that the overall strategy that accomplishes all of these goals is an intrinsic program running over time within the retinal progenitor cells.
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