BMI LEN Seminar - “Bidirectional optogenetic control of motoneuron and muscle activity"
Event details
| Date | 02.09.2013 |
| Hour | 13:00 |
| Location | |
| Category | Conferences - Seminars |
Abstract
Optogenetics employs light-sensitive proteins, called opsins, expressed in neuronal membranes to facilitate optical excitation or inhibition of neurons. Our laboratory is investigating applications of optogenetics in the peripheral nervous system using transgenic and viral approaches for delivery of opsins to targeted peripheral neurons. I will describe both optical excitation and inhibition of motoneurons measured in muscle force and electromyographic activity as well as our methods for controlling motoneuron activity in awake and freely moving rodents. These approaches can be broadly applied to study neuromuscular control and provide therapeutic insights into disorders of the peripheral nervous system.
Optogenetics employs light-sensitive proteins, called opsins, expressed in neuronal membranes to facilitate optical excitation or inhibition of neurons. Our laboratory is investigating applications of optogenetics in the peripheral nervous system using transgenic and viral approaches for delivery of opsins to targeted peripheral neurons. I will describe both optical excitation and inhibition of motoneurons measured in muscle force and electromyographic activity as well as our methods for controlling motoneuron activity in awake and freely moving rodents. These approaches can be broadly applied to study neuromuscular control and provide therapeutic insights into disorders of the peripheral nervous system.
Practical information
- Informed public
- Free
Organizer
- Holly Liske | Stanford University | USA
Contact
- Ursula Zwahlen