BMI SEMINAR // Cerebral cortex interneuron myelination: Fundamental mechanisms and clinical implications
Event details
Date | 19.12.2018 |
Hour | 12:15 › 13:15 |
Speaker | Steven Kushner, Department of Psychiatry, Erasmus MC: University Medical Center Rotterdam, The Netherlands |
Location | |
Category | Conferences - Seminars |
Previous studies have identified well-replicated structural abnormalities of white matter in schizophrenia, including in first-episode and treatment-naive patients. However, the causality of these changes has been difficult to ascertain. Seemingly unrelated abnormalities of parvalbumin (PV) interneurons in schizophrenia post-mortem neocortex have also been consistently observed, the leading candidate mechanism for disease-related deficits in gamma oscillations. In my talk, I will describe our findings combining family-based rare variant genetic discovery with induced pluripotent stem cell (iPSC) modeling which now suggest that oligodendrocyte progenitor cell dysfunction should be considered as a candidate etiological cell type in schizophrenia. Moreover, I will also discuss our discovery that fast-spiking PV interneurons in the neocortex and hippocampus are universally myelinated and exhibit a novel form of activity-dependent myelin plasticity, which could therefore represent an important locus of pathophysiological convergence.
Practical information
- Informed public
- Free
Organizer
- SV BMI Host : J. Gràff & C. Sandi