Conferences - Seminars
BMI Seminar // Habenular circuits for aversion encoding
By Manuel Mameli, Department of Fundamental Neurosciences, Faculty of Biology and Medicine, UNIL, Switzerland
Stress-related experience trigger circuit reorganisation, and if persistent contributes to the emergence of depressive symptoms. Therefore understanding the cellular basis of stress can ultimately lead to the identification of substrates potentially relevant for therapeutic interventions for depression. The lateral habenula, an epithalamic structure, encode negative stimuli and its dysfunction contributes to aspects of depressive-like phenotypes.
Our laboratory collected evidence indicating that stressors of different nature not only modify habenular activity but that this occurs via a reduction of inhibitory transmission. I will discuss the cellular event leading to habenular hyperactivity and discuss potential pharmacological or stimulation-based approaches that might have a therapeutical value.
Organization SV BMI Host: J. Gräff
Accessibility Informed public