BMI Seminar // Hailan Hu: From pecking order to ketamine - neural mechanism of social and emotional behavior


Event details

Date 21.06.2023
Hour 16:0017:00
Speaker Hailan Hu, Zhejiang University School of Medicine, Hangzhou, China
Location Online
Category Conferences - Seminars
Event Language English

Emotions and social interactions color our lives and shape our behaviors. Using animal models and engineered manipulations, we aim to understand how social and emotional behaviors are encoded in the brain, focusing on the neural circuits underlying dominance hierarchy and depression. This lecture will highlight our recent discoveries on how downward social mobility leads to depression; how ketamine tames depression by blocking burst firing in the brain’s anti-reward center; and, how glia-neuron interaction plays a surprising role in this process. I will also present our recent work on the mechanism underlying the sustained antidepressant activity of ketamine and its brain region specificity. With these results, we hope to illuminate on a more unified theory on ketamine’s mode of action and inspire new treatment strategies for depression.