BMI Seminar "To eat to not to eat: mitophagy in neurodegeneration"
Event details
| Date | 10.05.2017 |
| Hour | 12:15 › 13:15 |
| Speaker | Elena Ziviani, Department of Biology, University of Padova, Padova & Istituto IRCCS San Camillo, Lido di Venezia, Venezia, Italy |
| Location | |
| Category | Conferences - Seminars |
During mitophagy, impaired in genetic Parkinson’s disease (PD), the kinase PINK1 recruits the E3 ubiquitin ligase Parkin to damaged mitochondria. Increased Parkin levels correct PINK1 deficient Drosophila PD models, suggesting that targeting the Parkin-opposing deubiquitination enzymes (DUBs) can yield the same result. A targeted RNA interference screening for DUBs antagonizing Parkin ubiquitination of its key mitochondrial target Mitofusin identified six DUBs among which USP8 caught our attention. Biochemical and functional analyses indicated that USP8 impinges on mitochondria dysfunction via Parkin and that genetic and pharmacological inhibition of USP8 rescues a Drosophila model of PD. Our data identify a novel therapeutic target antagonizing pathologic symptoms in a model of PD
Practical information
- Informed public
- Free
Organizer
- SV BMI Host : H. Lashuel