*CANCELLED* --- A Modular Receptor Platform to Expand the Sensing Repertoire of Bacteria
Cancelled
Event details
| Date | 04.06.2018 |
| Hour | 12:15 › 13:15 |
| Speaker | Prof. Jérôme Bonnet, University of Montpellier (F) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR (cancelled)
Abstract:
Engineered bacteria promise to revolutionize diagnostics, therapeutics, and environmental remediation. Yet, many applications are precluded by the limited number of detectable signals. We designed a synthetic receptor platform enabling bacteria to respond to novel ligands. These receptors are activated via ligand-induced dimerization of a single-domain antibody fused to monomeric DNA-Binding Domains (split-DBDs). Once dimerized, the transcriptional function of the DBD is restored. We highlight several receptors design principles, show scalability, and downstream signal processing. This modular platform could be deployed into various hosts to detect ligands for which no receptor is found in nature.
Bio:
Currently group leader at the Centre de Biochimie Structurale, University of Montpellier, France
fellow from the Stanford Center on Longevity from 2009-2012
post-doc in the Endy Lab at Stanford University from 2008 to 2013
2007, PhD in cell and molecular biology, University of Montpellier (CRBM-CNRS UMR5237), France.
2003, MS in Biological science and health, University of Montpellier.
2001, BS in Biochemistry, University of Montpellier.
Abstract:
Engineered bacteria promise to revolutionize diagnostics, therapeutics, and environmental remediation. Yet, many applications are precluded by the limited number of detectable signals. We designed a synthetic receptor platform enabling bacteria to respond to novel ligands. These receptors are activated via ligand-induced dimerization of a single-domain antibody fused to monomeric DNA-Binding Domains (split-DBDs). Once dimerized, the transcriptional function of the DBD is restored. We highlight several receptors design principles, show scalability, and downstream signal processing. This modular platform could be deployed into various hosts to detect ligands for which no receptor is found in nature.
Bio:
Currently group leader at the Centre de Biochimie Structurale, University of Montpellier, France
fellow from the Stanford Center on Longevity from 2009-2012
post-doc in the Endy Lab at Stanford University from 2008 to 2013
2007, PhD in cell and molecular biology, University of Montpellier (CRBM-CNRS UMR5237), France.
2003, MS in Biological science and health, University of Montpellier.
2001, BS in Biochemistry, University of Montpellier.
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)