Chan Zuckerberg Initiative – Advancing Technologies for Spatiotemporal Omics in Live Tissue
Event details
| Date | 13.11.2025 |
| Category | Conferences - Seminars |
Aim: There is an urgent need for innovative, biocompatible, minimally invasive sampling and analytical technologies that enable real-time, high-resolution interrogation of proteomic and metabolomic landscapes in live tissues. With a focus on immunology and autoimmune disease, this program aims to catalyze the creation of scalable, engineering-driven solutions that support both ex vivo and in vivo applications.
The RFA program will be centered on the development of instrumented tissues that provide precise spatiotemporal insights into immune processes in tissue and disease models. To achieve this, CZI supports interdisciplinary collaborations at the nexus of bioengineering, systems biology, and AI. For more details on the scope of the call, see the RFA.
Two funding lines will be made available: Focused projects, for exploratory, risky technology development strategies, and Expanded projects, for projects that provide end-to-end solutions for live tissue proteomics and/or metabolomics.
Funding: $600,000 for Focused projects, or $1M for Expanded projects
Duration: 24 months
Eligibility: Applications may be submitted by domestic and foreign nonprofit organizations, including public and private institutions. Teams may include a total of up to three PIs; Each application must have one Coordinating PI, but may designate up to three total PIs. Tenure track faculty are eligible, as well as Non-tenure track faculty or staff scientists who lead a lab or are engaged in academic activities and are permitted to apply for grants by their institution. Early-career investigators are strongly encouraged to apply.
How to Apply: All applications must be completed and submitted through CZI’s online grants management portal at https://apply.chanzuckerberg.com. Applications should include PI details, organization details, a proposal and budget, Biosketches for all PIs, and optional letters of commitment. Detailed application instructions are available in the RFA, as well as in the grants management portal. Decisions will be returned in late February 2026, with projects expected to begin on 1 April 2026.
Deadline: 13 November 2025 (5 p.m. ET)
Further information:
The RFA program will be centered on the development of instrumented tissues that provide precise spatiotemporal insights into immune processes in tissue and disease models. To achieve this, CZI supports interdisciplinary collaborations at the nexus of bioengineering, systems biology, and AI. For more details on the scope of the call, see the RFA.
Two funding lines will be made available: Focused projects, for exploratory, risky technology development strategies, and Expanded projects, for projects that provide end-to-end solutions for live tissue proteomics and/or metabolomics.
Funding: $600,000 for Focused projects, or $1M for Expanded projects
Duration: 24 months
Eligibility: Applications may be submitted by domestic and foreign nonprofit organizations, including public and private institutions. Teams may include a total of up to three PIs; Each application must have one Coordinating PI, but may designate up to three total PIs. Tenure track faculty are eligible, as well as Non-tenure track faculty or staff scientists who lead a lab or are engaged in academic activities and are permitted to apply for grants by their institution. Early-career investigators are strongly encouraged to apply.
How to Apply: All applications must be completed and submitted through CZI’s online grants management portal at https://apply.chanzuckerberg.com. Applications should include PI details, organization details, a proposal and budget, Biosketches for all PIs, and optional letters of commitment. Detailed application instructions are available in the RFA, as well as in the grants management portal. Decisions will be returned in late February 2026, with projects expected to begin on 1 April 2026.
Deadline: 13 November 2025 (5 p.m. ET)
Further information:
- More information about the program can be found here
- For help on the Institutional Approval Form, contact the Research Office
- Any other questions, including on the budget, can also be directed to the Research Office
Practical information
- General public
- Free