ChemBio e-seminar by Prof. Danica Fujimori
Event details
| Date | 15.03.2022 |
| Speaker | https://pharmacy.ucsf.edu/danica-galonic-fujimori |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
Title: Chemical Biology of Methylation-Dependent Chromatin Recognition
Abstract: Lysine methylation is a functionally diverse chromatin modification that regulates a number of cellular processes including heterochromatin formation, transcriptional regulation and DNA repair. The spatial and temporal control of histone methylation is achieved by opposing activities of histone modifying enzymes - methyltransferases, enzymes that deposit methylation marks, and demethylases, enzymes that remove them. Methylation states of chromatin are recognized by methylation reader domains. Misregulation of methylation is associated with disease, including cancer and neurodegeneration, and inhibitors of methylation regulators offer promising new avenue in oncology. In this talk, I will discuss our recent efforts on understanding functions of plant homeodomain family of readers of chromatin methylation, and development of modulators for this family of epigenetic proteins.
Speaker's Biography: Danica Galonić Fujimori is a professor of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry, associate director of Quantitative Biosciences Institute and associate director of Chemical Biology graduate program at University of California in San Francisco. Organic chemist by graduate training (2005 PhD from UIUC, with Wilfred van der Donk and the late David Gin) and mechanistic enzymologist by postdoctoral training (with Chris Walsh at Harvard Medical School, 2008), her lab combines organic chemistry and biochemical reconstitution to investigate posttranslational and posttranscriptional regulation of macromolecules. Her work has been recognized by a number of awards including V foundation Scholar, NSF Career award, Searle Scholar, and WM Keck Medical Research Award.
Lab website: http://fujimorilab.ucsf.edu
Abstract: Lysine methylation is a functionally diverse chromatin modification that regulates a number of cellular processes including heterochromatin formation, transcriptional regulation and DNA repair. The spatial and temporal control of histone methylation is achieved by opposing activities of histone modifying enzymes - methyltransferases, enzymes that deposit methylation marks, and demethylases, enzymes that remove them. Methylation states of chromatin are recognized by methylation reader domains. Misregulation of methylation is associated with disease, including cancer and neurodegeneration, and inhibitors of methylation regulators offer promising new avenue in oncology. In this talk, I will discuss our recent efforts on understanding functions of plant homeodomain family of readers of chromatin methylation, and development of modulators for this family of epigenetic proteins.
Speaker's Biography: Danica Galonić Fujimori is a professor of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry, associate director of Quantitative Biosciences Institute and associate director of Chemical Biology graduate program at University of California in San Francisco. Organic chemist by graduate training (2005 PhD from UIUC, with Wilfred van der Donk and the late David Gin) and mechanistic enzymologist by postdoctoral training (with Chris Walsh at Harvard Medical School, 2008), her lab combines organic chemistry and biochemical reconstitution to investigate posttranslational and posttranscriptional regulation of macromolecules. Her work has been recognized by a number of awards including V foundation Scholar, NSF Career award, Searle Scholar, and WM Keck Medical Research Award.
Lab website: http://fujimorilab.ucsf.edu
Practical information
- Informed public
- Free