ChemBio e-seminar by Prof. Xiao Wang - CH-635
Title: Mapping and designing mRNA translation in mammalian cells
Abstract:
The translation process from mRNA to protein is strictly regulated in mammalian cells. In order to gain deeper insights into mRNA translation, I will first introduce a high-resolution 3D in situ sequencing approach to simultaneously mapping the translation of thousands of genes in intact cells and tissues. I will then discuss how we can reimage and enhance mRNA translation and stability by creating mRNA-oligonucleotide conjugates for biomedical applications.
Speaker's biography:
Xiao Wang is a core institute member of the Broad Institute of MIT and Harvard and an assistant professor in the Department of Chemistry at MIT. She started her lab in 2019 to develop and apply new chemical, biophysical, and genomic tools to better understand and tune tissue function at the molecular level. Wang joined the MIT and Broad after conducting postdoctoral research at Stanford University. She received her B.S. in chemistry and molecular engineering from Peking University in 2010 and her Ph.D. in chemistry from the University of Chicago in 2015.
Lab website: https://www.wangxiaolab.org/
Abstract:
The translation process from mRNA to protein is strictly regulated in mammalian cells. In order to gain deeper insights into mRNA translation, I will first introduce a high-resolution 3D in situ sequencing approach to simultaneously mapping the translation of thousands of genes in intact cells and tissues. I will then discuss how we can reimage and enhance mRNA translation and stability by creating mRNA-oligonucleotide conjugates for biomedical applications.
Speaker's biography:
Xiao Wang is a core institute member of the Broad Institute of MIT and Harvard and an assistant professor in the Department of Chemistry at MIT. She started her lab in 2019 to develop and apply new chemical, biophysical, and genomic tools to better understand and tune tissue function at the molecular level. Wang joined the MIT and Broad after conducting postdoctoral research at Stanford University. She received her B.S. in chemistry and molecular engineering from Peking University in 2010 and her Ph.D. in chemistry from the University of Chicago in 2015.
Lab website: https://www.wangxiaolab.org/
Practical information
- Informed public
- Free