ChemBio seminar by Prof. Stephen Renshaw (Sheffield) - CH-635


Event details

Date 23.05.2024
Hour 16:1517:15
Speaker Prof. Stephen Renshaw
Category Conferences - Seminars
Event Language English
Title: Zebrafish models of innate immunity

Zebrafish are emerging as an excellent model for the study of innate immunity. Zebrafish larvae have neutrophils and macrophages from an early age, without any adaptive immune system. Combined with the transparency of the larvae and the genetic tractability of the system, it is possible to image many aspects of innate immune cell biology in vivo. We have exploited this system to broaden our understanding of innate immune cell function during infection and inflammatory injury, with implications for the study of human disease. Our results are applicable to antimicrobial resistant infection and infectious/inflammatory diseases such as COPD and cystic fibrosis.
In this talk I will present our history as a pioneering group using the zebrafish model to study innate immunity and show unpublished data from ongoing projects in inflammation and infection.

Speaker's biography:
I am the Sir Arthur Hall Professor of Medicine at the University of Sheffield and Honorary Consultant Respiratory Physician at Sheffield Teaching Hospitals NHS Foundation Trust.
I am currently Head of Division of Clinical Medicine within the School of Medicine and Population Health leading a division of 450 staff and around 1800 students.
I am Director of the Bateson Centre, a University Research Centre, built around zebrafish models of disease, with around 40 PIs and over £20m of active funding.
I am also Deputy Faculty Director of Research and Innovation in the Faculty of Health, and Faculty REF lead (REF is our Research Excellence Framework, a 7 yearly assessment of research performance that determines a large part of the University income).
I studied undergraduate medicine at the University of Cambridge and clinical medicine at Oxford University Medical School. After a clinical rotation in Nottingham, I moved to Sheffield to take up a Wellcome Trust Clinical Research Training Fellowship, to complete a PhD on the regulation of neutrophil lifespan with Professor Moira Whyte.
After 3 years as Clinical Lecturer in Respiratory Medicine, I was awarded an MRC Clinician Scientist Fellowship to use zebrafish to study inflammation resolution. In 2008 I was awarded an MRC Senior Clinical Fellowship and in 2014 an MRC Programme Grant to continue this work.
 I continue clinical work in Respiratory Medicine with a special interest in Interstitial Lung Disease associated with multisystem inflammatory disease (sarcoidosis and connective tissue disease predominantly).

Lab website:


Practical information

  • Informed public
  • Free