Computational Design of Self-Assembling Peptides and Proteins

Event details
Date | 06.12.2019 |
Hour | 10:00 › 11:00 |
Speaker | Prof. Ingemar André, Lund University (SE) |
Location | |
Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Many of the largest protein complexes in biology are composed of a single type of subunit that is repeated a large number of times to generate a functional assembly. Such homomeric structures are often assembled spontaneously from individual components through the process of self-assembly. Research in our group is focused on the prediction of the three-dimensional structure of homomeric assemblies and the rational design of novel self-assembling proteins and peptides. I will demonstrate how protein design can be used to develop a self-assembling protein container system for selective encapsulation of proteins. I will also describe the development of a peptide with a pH dependent oligomerization switch, with applications as pH sensitive control elements that can control assembly of larger proteins.
Abstract:
Many of the largest protein complexes in biology are composed of a single type of subunit that is repeated a large number of times to generate a functional assembly. Such homomeric structures are often assembled spontaneously from individual components through the process of self-assembly. Research in our group is focused on the prediction of the three-dimensional structure of homomeric assemblies and the rational design of novel self-assembling proteins and peptides. I will demonstrate how protein design can be used to develop a self-assembling protein container system for selective encapsulation of proteins. I will also describe the development of a peptide with a pH dependent oligomerization switch, with applications as pH sensitive control elements that can control assembly of larger proteins.
Practical information
- Informed public
- Free
- This event is internal