Connectomics to Biotextilogy - Thinking Inversely and Recursively to Engineer Advanced Materials and Medical Devices
Event details
| Date | 14.05.2018 |
| Hour | 12:15 › 13:15 |
| Speaker | Prof. Melissa L. Knothe Tate, University of New South Wales, Sydney (AUS) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
(sandwiches will be served)
Abstract:
Through combination of novel microscopy protocols for imaging live cells and tissues as well as experimental mechanics methods, we have begun to elucidate mechanisms underpinning emergent properties of hierarchical materials such as tissues [1,2]. We refer to the process as Microscopy Aided Design And Manufacture (MADAMe). We apply this paired imaging and computational technology approach to engineer advanced materials that emulate the smart mechanical properties of tissues. These materials have applications in diverse arenas, from medical implants to the transport and sports industries. Our "bottom up" approach to emulating mechanically responsive natural materials integrates the fields of multiscale biomechanics and mechanobiology in novel ways and underscores the role of mechanics in life. It also elucidates how "brainless" cells adapt to dynamic mechanical environments by constantly weaving and thereby adapting their own niche [3]. In addition, our connectomics approach to understanding cell networks in situ, in tissues as diverse as brain and bone, provides a basis for a new approach to diagnostics, predicting emergent disease states using an epidemiological approach in cell populations within individual patients [3,5,6]. Challenges to the connectomics approach include acquisition, handling and archiving of massive data sets, discrepancies in technical capacities (e.g. resolution) of imaging methods, and hard and software approaches, as well as bridging and upskilling of research teams to apply a transdisciplinary approach using innovative conceptual, experimental, and translational approaches. This talk integrates our understanding of cells, expert tissue prototypers, and their networks, to emulating cellular approaches to engineer and manufacture materials and medical devices of the future.
[1] Knothe Tate ML (2017) Science/AAAS, A New Age in Scanning Electron Microscopy: Applications in the Life Sciences, pp. 19-23.
[2] Ng J et al. Sci Reports (2017) 7, 40396.
[3] Knothe Tate ML et al. Adv Healthcare Mat (2016) 5, 1581.
[4] Knothe Tate ML et al. BioArchitecture (2016) 6, 85.
[5] Eberle A-L et al. J Microscopy (2015) 259, 114.
[6] Pereira A et al. PLoS Comp Biol (2016) 12, e1005217.
Bio:
Experience
since 2013:
University of New South Wales, Sidney (AUS)
Professor, Paul Trainor Chair of Biomedical Engineering
2009-2013:
Case Western Reserve University, Cleveland, OH (USA)
Professor, Mechanical & Aerospace and Biomedical Engineering
2004-2009:
Case Western Reserve University, Cleveland, OH (USA)
Associate Professor, Mechanical & Aerospace and Biomedical Engineering
2001-2004:
Case Western Reserve University, Cleveland, OH (USA)
Adjunct Assistant Professor, Mechanical & Aerospace and Biomedical Engineering
2001-2002:
University and ETH Zurich (CH)
Adjunct Lecturer, Institute of Biomedical Engineering and Medical Informatics
2000:
Mount Sinai School of Medicine, New York (USA)
Visiting Professor, Department of Orthopaedics
1998-2000:
University and ETH Zurich (CH)
Lecturer, Head of Mechanobiology Research Group, Institute of Biomedical Engineering and Medical Informatics
1997-2000:
AO/ASIF Research Institute, Davos (CH)
Head of Bone Mechanobiology Research Group
1997-1998:
ETH Zurich (CH)
Postdoctoral fellow, Institute of Biomedical Engineering and Medical Informatics
Education
ETH Zurich (CH)
Ph.D., Mechanical Engineering and Biomedical Engineering (1998)
M.S., Mechanical Engineering (1994)
Stanford University (USA)
B.S., Mechanical Engineering and B.S., Biological Sciences (dual degrees, 1988)
(sandwiches will be served)
Abstract:
Through combination of novel microscopy protocols for imaging live cells and tissues as well as experimental mechanics methods, we have begun to elucidate mechanisms underpinning emergent properties of hierarchical materials such as tissues [1,2]. We refer to the process as Microscopy Aided Design And Manufacture (MADAMe). We apply this paired imaging and computational technology approach to engineer advanced materials that emulate the smart mechanical properties of tissues. These materials have applications in diverse arenas, from medical implants to the transport and sports industries. Our "bottom up" approach to emulating mechanically responsive natural materials integrates the fields of multiscale biomechanics and mechanobiology in novel ways and underscores the role of mechanics in life. It also elucidates how "brainless" cells adapt to dynamic mechanical environments by constantly weaving and thereby adapting their own niche [3]. In addition, our connectomics approach to understanding cell networks in situ, in tissues as diverse as brain and bone, provides a basis for a new approach to diagnostics, predicting emergent disease states using an epidemiological approach in cell populations within individual patients [3,5,6]. Challenges to the connectomics approach include acquisition, handling and archiving of massive data sets, discrepancies in technical capacities (e.g. resolution) of imaging methods, and hard and software approaches, as well as bridging and upskilling of research teams to apply a transdisciplinary approach using innovative conceptual, experimental, and translational approaches. This talk integrates our understanding of cells, expert tissue prototypers, and their networks, to emulating cellular approaches to engineer and manufacture materials and medical devices of the future.
[1] Knothe Tate ML (2017) Science/AAAS, A New Age in Scanning Electron Microscopy: Applications in the Life Sciences, pp. 19-23.
[2] Ng J et al. Sci Reports (2017) 7, 40396.
[3] Knothe Tate ML et al. Adv Healthcare Mat (2016) 5, 1581.
[4] Knothe Tate ML et al. BioArchitecture (2016) 6, 85.
[5] Eberle A-L et al. J Microscopy (2015) 259, 114.
[6] Pereira A et al. PLoS Comp Biol (2016) 12, e1005217.
Bio:
Experience
since 2013:
University of New South Wales, Sidney (AUS)
Professor, Paul Trainor Chair of Biomedical Engineering
2009-2013:
Case Western Reserve University, Cleveland, OH (USA)
Professor, Mechanical & Aerospace and Biomedical Engineering
2004-2009:
Case Western Reserve University, Cleveland, OH (USA)
Associate Professor, Mechanical & Aerospace and Biomedical Engineering
2001-2004:
Case Western Reserve University, Cleveland, OH (USA)
Adjunct Assistant Professor, Mechanical & Aerospace and Biomedical Engineering
2001-2002:
University and ETH Zurich (CH)
Adjunct Lecturer, Institute of Biomedical Engineering and Medical Informatics
2000:
Mount Sinai School of Medicine, New York (USA)
Visiting Professor, Department of Orthopaedics
1998-2000:
University and ETH Zurich (CH)
Lecturer, Head of Mechanobiology Research Group, Institute of Biomedical Engineering and Medical Informatics
1997-2000:
AO/ASIF Research Institute, Davos (CH)
Head of Bone Mechanobiology Research Group
1997-1998:
ETH Zurich (CH)
Postdoctoral fellow, Institute of Biomedical Engineering and Medical Informatics
Education
ETH Zurich (CH)
Ph.D., Mechanical Engineering and Biomedical Engineering (1998)
M.S., Mechanical Engineering (1994)
Stanford University (USA)
B.S., Mechanical Engineering and B.S., Biological Sciences (dual degrees, 1988)
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)