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Daily Light and Darkness Onset Metabolically Control Hematopoietic Stem Cell Function

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Event details

Date and time 11.02.2019 12:15  
Place and room
Speaker Prof. Tsvee Lapidot, Weizmann Institute of Science, Rehovot, Israel
Category Conferences - Seminars
(sandwiches served)

Hematopoietic stem and progenitor cells (HSPC) are essential for mature blood cell production, host immunity and osteoclast mediated bone turnover. When do stem cells give rise to all mature blood cells while maintaining their pool and how these opposite tasks are synchronized is poorly understood. Recent studies revealed that daily onset of light and darkness differentially control HSPC migration and differentiation while maintaining their bone marrow (BM) reservoir by inducing circadian bursts of BM norepinephrine (NE), TNF and melatonin. Bone forming stromal precursors are also regulated by daylight and darkness onset. The metabolic cross talk between blood and bone forming stem cells which protects hematopoietic stem cells from chemotherapy insult and the potential role of stress induced mitochondria transfer will be presented.  These topics and their clinical potential will be discussed.

1990-1994:   Post-Doc. Hospital for Sick Children, University of Toronto, Canada.
1985-1990:   Ph.D. Weizmann Institute, Rehovot, IL.
1983-1985:   M.Sc. Weizmann Institute, Rehovot, IL.
1980-1983:   B.Sc. The Hebrew University, Jerusalem, IL.

2006 - Present:   Professor, Department of Immunology, Weizmann Institute.
2001 - 2006:   Associate Professor, Department of Immunology, Weizmann Institute.
1994 - 2001:   Senior Scientist. Department of Immunology, Weizmann Institute.


Practical information

  • Informed public
  • Free