Dissecting cancer metastasis through the analysis of circulating tumor cells
Event details
| Date | 13.06.2016 |
| Hour | 11:00 |
| Speaker | Dr. Nicola Aceto, University of Basel |
| Location | |
| Category | Conferences - Seminars |
Prof. Aceto's group is interested in understanding the molecular mechanisms that drive the development and maintenance of cancer metastasis, with a particular focus on the analysis of circulating tumor cells. In our studies, we use a combination of microfluidics technologies, patient samples, in vivo models, next-generation sequencing, molecular and computational biology to study how cancer spreads. We strive to identify metastasis-specific therapeutic targets to enable the development of new therapies that will suppress this disease.
They recently reported that CTC-clusters, i.e. cancer cell aggregates in circulation held together by interepithelial cell-cell junctions, are precursors of breast cancer metastasis (Aceto et al., Cell, 2014) . They have developed a new microfluidics device with specialized bifurcating traps to isolate CTCs from patients with metastatic breast or prostate cancer or melanoma (Sarioglu and Aceto et al., Nature Methods, 2014).
They recently reported that CTC-clusters, i.e. cancer cell aggregates in circulation held together by interepithelial cell-cell junctions, are precursors of breast cancer metastasis (Aceto et al., Cell, 2014) . They have developed a new microfluidics device with specialized bifurcating traps to isolate CTCs from patients with metastatic breast or prostate cancer or melanoma (Sarioglu and Aceto et al., Nature Methods, 2014).
Practical information
- General public
- Free
Organizer
- Joerg Huelsken <[email protected]>
Contact
- Joerg Huelsken <[email protected]>