EPFL BioE Talks SERIES "Interplay Between Lipid Membrane Mechanics and Proteins’ Diffusion, Clustering and Function"


Event details

Date 26.02.2024
Hour 12:1513:15
Speaker Prof. Patricia Bassereau, CNRS Research Director, Institut Curie, Paris (F)
Location Online
Category Conferences - Seminars
Event Language English
WEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)

Cell membranes are highly deformable and have to be strongly curved, for instance upon trafficking when small buds form and eventually detach from cell membranes. Membrane-shaping processes always require proteins, in particular proteins with intrinsically-curved shapes or transmembrane proteins with conical shapes. Moreover, since cell membranes are fluid, proteins can diffuse on/in membranes, which allows them to redistribute depending on membrane shape changes. In vitro membrane systems with controlled curvature, combined to theoretical models, have been instrumental for understanding the rich interplay between membrane shape/tension, protein distribution and lateral diffusion. I will summarize some results we have obtained with in vitro membrane systems and reconstituted trans-membrane protein on membrane curvature-induced protein sorting, on protein diffusion and clustering and on the effect of membrane curvature on transport activity.

Patricia Bassereau is CNRS Directrice de Recherche at the Institut Curie in Paris, France, where she is the leader of the group "Membranes and cellular functions". She obtained a short PhD and a PhD in Soft Matter at the University of Montpellier where she started her career on the structure of self-assembled surfactant-based systems. She spent one year as a visiting scientist at the IBM Almaden Center (San Jose, CA, USA) on thin polymer films. She moved to the Institut Curie in 1993 to work on questions related to "Physics of the cell". She develops a multidisciplinary approach, largely based on synthetic biology and biomimetic systems, as well as quantitative mechanical and microscopy methods to understand the role of biological membranes and of their organization in cellular functions such as intracellular trafficking, endo/exocytosis or adhesion. Additionally, she studies in vitro and in cellulo the mechanics and the generation of cellular protrusions. In parallel, she contributes to a more comprehensive physical description of biomembranes by studying the consequences of non-equilibrium transmembrane transport of ions on membrane mechanics ("active membranes"), the relation between membrane proteins' shape and their diffusion or their lateral distribution on membranes.

Master: Solid State Physics (1983)
PhD (1985)
PhD (1990)
HdR (Habilitation, 1999)

GDPC-Montpellier (1983-1991)
IBM Almaden (USA) (1992)
Physical Chemistry Curie-Paris (1993-Present)

Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks

Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
  1. send D. Reinhard a note well ahead of time (ideally before seminar day), informing that you plan to attend the talk online, and, during seminar:
  2. be signed in on Zoom with a recognizable user name (not any alias making it difficult or impossible to identify you).
Students attending the seminar in-person should collect a confirmation signature after the talk - please print your own signature sheet beforehand (71 kB pdf available for download here). IMPORTANTLY: hang on to this sheet as no signature record is being kept by anyone else!

Practical information

  • Informed public
  • Registration required