EPFL BioE Talks SERIES "The Context-Dependent Function of Chromatin Modifications"
Event details
| Date | 12.12.2022 |
| Hour | 16:00 › 17:00 |
| Speaker | James Hackett, Ph.D., Group Leader, EMBL Rome, Monterotondo (IT) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
WEEKLY EPFL BIOE TALKS SERIES
Abstract:
Control of chromatin structure and accessibility is a central mechanism for the regulation and propagation of gene expression programs. Histone modifications contribute to this mechanism, but their precise role in mediating quantitative transcriptional responses and cellular memory is incompletely understood. Indeed, it remains debated whether chromatin modification states directly trigger transcription or whether they simply reflect a consequence of expression across cellular and genomic environments. Understanding this is important to establish the function of dynamic epigenomic landscapes associated with cell identity and fate transitions. Here, I will first present our attempts to deconvolve chromatin regulation at the level of global epigenome (re)programming events during early mammalian development. I will then discuss how precision technologies can capture the context-dependent and quantitative function of chromatin modifications on transcriptional regulation and memory.
Bio:
PhD, 2010, University of Edinburgh, UK.
Postdoctoral research at the Gurdon Institute, University of Cambridge, UK.
Group leader at EMBL since 2016.
Joint appointment with the Genome Biology Unit.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IF you are not attending in-person in the room, please make sure to
Abstract:
Control of chromatin structure and accessibility is a central mechanism for the regulation and propagation of gene expression programs. Histone modifications contribute to this mechanism, but their precise role in mediating quantitative transcriptional responses and cellular memory is incompletely understood. Indeed, it remains debated whether chromatin modification states directly trigger transcription or whether they simply reflect a consequence of expression across cellular and genomic environments. Understanding this is important to establish the function of dynamic epigenomic landscapes associated with cell identity and fate transitions. Here, I will first present our attempts to deconvolve chromatin regulation at the level of global epigenome (re)programming events during early mammalian development. I will then discuss how precision technologies can capture the context-dependent and quantitative function of chromatin modifications on transcriptional regulation and memory.
Bio:
PhD, 2010, University of Edinburgh, UK.
Postdoctoral research at the Gurdon Institute, University of Cambridge, UK.
Group leader at EMBL since 2016.
Joint appointment with the Genome Biology Unit.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IF you are not attending in-person in the room, please make sure to
- send D. Reinhard a note before noon on seminar day, informing that you plan to attend the talk online, and
- be signed in on Zoom with a recognizable user name (not a pseudonym making it difficult or impossible to be identified).
Practical information
- Informed public
- Registration required
Organizer
- Prof. David Suter, EPFL
Contact
- Institute of Bioengineering (IBI), Dietrich REINHARD