EPFL BioE Talks SERIES "Understanding and Controlling Mechanotransduction, From Integrins to the Nucleus"
Event details
| Date | 25.11.2024 |
| Hour | 12:15 › 13:15 |
| Speaker | Prof. Pere Roca-Cusachs Soulere, Institute for Bioengineering of Catalonia (IBEC) and Universitat de Barcelona (ES) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
WEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)
Abstract:
Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the properties of the extracellular matrix (ECM), including its mechanical rigidity and its composition. In this talk, I will discuss how mechanical force is transmitted from the ECM to the nucleus, and how this affects proteins in general, and transcription factors in particular, by controlling their shuttling between the cytoplasm and nucleus. Further, I will discuss how this knowledge can be used to control, and potentially engineer, cell mechanotransduction.
Bio:
Pere Roca-Cusachs obtained his PhD in cellular biophysics in 2007 from the Medical School at the University of Barcelona. He then worked in the lab of Prof. Michael Sheetz (Department of Biological Sciences, Columbia University) as a post-doctoral researcher until 2011. In 2011, He joined the University of Barcelona, where he is now full professor. In 2012, he obtained a joint position as group leader at the Institute for Bioengineering of Catalonia (IBEC). He is an EMBO member and a recipient of the EMBO Young Investigator Award, the 2017 City of Barcelona award to the Life Sciences, the 2017 Young Investigator Award of the European Biophysical Societies Association (EBSA), and an advanced grant from the ERC. The research of his group focuses on unraveling the physical and molecular mechanisms by which cells detect and respond to mechanical force.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
Abstract:
Cell proliferation and differentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the properties of the extracellular matrix (ECM), including its mechanical rigidity and its composition. In this talk, I will discuss how mechanical force is transmitted from the ECM to the nucleus, and how this affects proteins in general, and transcription factors in particular, by controlling their shuttling between the cytoplasm and nucleus. Further, I will discuss how this knowledge can be used to control, and potentially engineer, cell mechanotransduction.
Bio:
Pere Roca-Cusachs obtained his PhD in cellular biophysics in 2007 from the Medical School at the University of Barcelona. He then worked in the lab of Prof. Michael Sheetz (Department of Biological Sciences, Columbia University) as a post-doctoral researcher until 2011. In 2011, He joined the University of Barcelona, where he is now full professor. In 2012, he obtained a joint position as group leader at the Institute for Bioengineering of Catalonia (IBEC). He is an EMBO member and a recipient of the EMBO Young Investigator Award, the 2017 City of Barcelona award to the Life Sciences, the 2017 Young Investigator Award of the European Biophysical Societies Association (EBSA), and an advanced grant from the ERC. The research of his group focuses on unraveling the physical and molecular mechanisms by which cells detect and respond to mechanical force.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
- send D. Reinhard a note well ahead of time (ideally before seminar day), informing that you plan to attend the talk online, and, during seminar:
- be signed in on Zoom with a recognizable user name (not any alias making it difficult or impossible to identify you).
Practical information
- Informed public
- Registration required
Organizer
- Prof. Li Tang, Institute of Bioengineering
Contact
- Institute of Bioengineering (IBI), Dietrich REINHARD