Epigenetic Control of HPV Chromatin-Dependent Transcription
Event details
| Date | 27.01.2011 |
| Hour | 16:00 |
| Speaker | Cheng-Ming Chiang, Southwestern Medical Center, Dallas |
| Location |
SV 1717 A
|
| Category | Conferences - Seminars |
Transcription in higher eukaryotes is controlled by an array of transcription factors, including the general transcription machinery, general cofactors, and gene-specific activators and repressors. The complexity of gene regulation is further conferred by the existence of multiple protein family members recognizing consensus or non-canonical DNA-binding sequences. The chromatin structure in the human genome and posttranslational modification on protein molecules provide an additional level of control in modulating gene activity. In this lecture, I will review these control mechanisms using human papillomavirus (HPV) E6 and E2 proteins as examples to illustrate how DNA tumor virus-encoded transcriptional regulators are able to reprogram cellular activities by targeting p53 tumor suppressor protein and activator protein-1 (AP-1), respectively, via recruitment of distinct coregulators, such as p300 histone acetyltransferase and the chromatin adaptor bromodomain-containing protein 4 (Brd4). The interplay among these viral and cellular proteins and the crosstalk between different posttranslational modifications regulate gene activity in response to various environmental stresses.
Practical information
- General public
- Free
Organizer
- Didier Trono
Contact
- Didier Trono