Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: implications for local immune homeostasis
Event details
| Date | 16.05.2011 |
| Hour | 14:00 |
| Speaker | Thomas BRUNNER -Professor & Chair in Biochemical Pharmacology, University of Konstanz, Germany |
| Location | |
| Category | Conferences - Seminars |
Glucocorticoids are potent endogenous and therapeutically administered steroids with widespread activities in metabolism and immune regulation. Though produced at large quantities in the adrenal glands, there is increasing evidence for an important role of extra-adrenal sources of glucocorticoids in regulating tissue-specific processes. We have recently shown that the intestinal crypt cells synthesize and release glucocorticoids in response to immune cell stimulation and that intestinal glucocorticoids have a critical role in the maintenance of intestinal immune homeostasis. In this presentation our studies on the regulation of glucocorticoid synthesis in the intestinal epithelium by cytokines and nuclear receptors, and its consequences for the regulation of inflammatory diseases of the intestinal mucosa will be discussed.
Practical information
- General public
- Free