Flexible microfabricated electrode arrays for Deep Brain Stimulation
Event details
| Date | 22.10.2015 |
| Hour | 16:15 |
| Speaker | Michel Decré, Medtronic Eidhoven Design Center |
| Location |
EPFL, CO2
|
| Category | Conferences - Seminars |
Deep brain stimulation (DBS) is approved worldwide for the treatment of Parkinson’s disease (PD), essential tremor, dystonia, obsessive-compulsive disorder (OCD) and more recently epilepsy, while other neurological and psychiatric disorders are under investigation. Starting in 2005 at Philips Research, we developed an innovative, microfabricated high-resolution DBS implant with the capacity to steer electrical pulses away from areas of the brain that can produce undesirable side-effects. The project was spun off as Sapiens in 2011, and finally acquired by Medtronic in 2014.
We will cover the key system architecture, engineering choices, and technology innovation elements of the steering DBS system. We will of course devote special attention to the thin-film manufacturing technology, the array connectivity, manufacturability, and some testing challenges. We will then discuss the intra-operative FAME (First–Acute-in-Man-Evaluation) pilot study performed at the Department of Neurosurgery , Academic Medical Center (AMC), Amsterdam, that was the first clinical investigation of Sapiens’ new high-resolution SureStim™ lead.
Finally, we will also include considerations of the innovation process, from initial invention, through spin-off, to “exit” as an acquisition.
Bio: Michel Decré, PhD, is founder and chief technology officer of Sapiens. He initiated and led the work on deep brain stimulation at Philips Research from 2006-2011 with a multidisciplinary team from Philips Research, Philips AppTech, and Philips MiPlaza. He successfully led the joint development project with Neuronexus Technologies Inc. in Ann Arbor, MI from 2008-2010.
Decré is renowned for his work on thin film technology, which is at the heart of Sapiens’ implant and co-invented numerous filed patents and applications in this field. He is a visiting professor at Leeds University. He was a member of the Dutch Organisation for Scientific Research (NWO-FOM) “Brain and Cognition” Scouting Commission, and of the technology watch foundation STT “Brain Visions” Study Group. Decré coordinated national and European Commission (EC)-subsidized projects (NAPS, Brainmimic) and was industrial coordinator of EC-funded Neuroprobes. The wave-printing technology he co-invented and developed with his Philips team from 2001-2005 was successfully transferred to Suess-MicroTech, Germany (SCIL technology, “Substrate Conformal Imprint Lithography”).
We will cover the key system architecture, engineering choices, and technology innovation elements of the steering DBS system. We will of course devote special attention to the thin-film manufacturing technology, the array connectivity, manufacturability, and some testing challenges. We will then discuss the intra-operative FAME (First–Acute-in-Man-Evaluation) pilot study performed at the Department of Neurosurgery , Academic Medical Center (AMC), Amsterdam, that was the first clinical investigation of Sapiens’ new high-resolution SureStim™ lead.
Finally, we will also include considerations of the innovation process, from initial invention, through spin-off, to “exit” as an acquisition.
Bio: Michel Decré, PhD, is founder and chief technology officer of Sapiens. He initiated and led the work on deep brain stimulation at Philips Research from 2006-2011 with a multidisciplinary team from Philips Research, Philips AppTech, and Philips MiPlaza. He successfully led the joint development project with Neuronexus Technologies Inc. in Ann Arbor, MI from 2008-2010.
Decré is renowned for his work on thin film technology, which is at the heart of Sapiens’ implant and co-invented numerous filed patents and applications in this field. He is a visiting professor at Leeds University. He was a member of the Dutch Organisation for Scientific Research (NWO-FOM) “Brain and Cognition” Scouting Commission, and of the technology watch foundation STT “Brain Visions” Study Group. Decré coordinated national and European Commission (EC)-subsidized projects (NAPS, Brainmimic) and was industrial coordinator of EC-funded Neuroprobes. The wave-printing technology he co-invented and developed with his Philips team from 2001-2005 was successfully transferred to Suess-MicroTech, Germany (SCIL technology, “Substrate Conformal Imprint Lithography”).
Practical information
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