“Functional and pathologic relevance of mitochondrial proteases: lessons from mutant mice”
Event details
| Date | 16.12.2013 |
| Hour | 10:30 › 11:30 |
| Speaker |
Pedro Moral QUIROS University of Oviedo, Dept. Bioquimica y Biologia Molecular, Oviedo (Asturias), Spain |
| Location | |
| Category | Conferences - Seminars |
Mitochondria are subcellular dynamic organelles responsible to generate the bulk of energy in the cell, regulate intermediate metabolism and control different other functions in the cell, such apoptosis and calcium metabolism. During evolution, mitochondria have generated a complex quality control system, composed by proteases and chaperones, that ensure the proper function of these organelles. Among all mitochondrial quality control proteases, only a few of them have a known function, whereas the physiological and cellular function of most of them remains unknown. We have generated mice deficient in two of these proteases, Oma1 and Lonp1, which exerts their quality control function at different levels. Oma1 is a metalloprotease of the mitochondrial inner membrane, which regulates mitochondrial dynamics, whereas Lonp1 is a serine protease of the mitochondrial matrix, associated with the processing and turnover of oxidized proteins. The generation of mice deficient in both proteases has allowed us to unveil the functional relevance of these proteases in different cellular processes and provide new views about their implications in different pathological conditions like metabolic diseases and cancer.
Practical information
- General public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx for the LIMNA Alliance
Contact
- Johan Auwerx