Functional Interrogation of the Cancer Genome
Event details
| Date | 01.05.2014 |
| Hour | 15:00 › 16:00 |
| Speaker | Prof. Kartiki Desai |
| Location | |
| Category | Conferences - Seminars |
Abstract: Extracellular receptors and/or secreted growth factors that drive cancer metastasis make provocative targets as they are easily accessible on the cell surface and usually show high response rates at lower drug doses, resulting in negligible side effects. To discover novel candidate receptor/secreted oncogenes, we used a whole-genome data-mining approach that takes advantage of large microarray studies of breast tumors annotated for clinical outcomes. Based on analysis of 14 independent breast cancer cohorts (2027 patients), we identified more than 30 cell surface/secreted proteins that when expressed highly, were associated with poor patient survival across multiple cohorts. This enriched gene set offered unexplored opportunities for immunotherapy and ?drug? development. We established a cell-based screening platform to prioritize the most clinically relevant genes, and explored pathways downstream to each candidate in order to develop assay read-outs. One candidate molecule, JMJD6, a bifunctional histone arginine demethylase and hydroxylase emerged as a marker of tumor aggressiveness, therapy resistance and affected both cell growth and motility. We will discuss molecular details involved and our efforts to understand its complete function in oncogenesis.
Practical information
- Informed public
- Free
Organizer
- Dr. Philipp Bucher
Contact
- Dr. Philipp Bucher