Functional Relevance of Mitochondrial DNA Methylation
Event details
| Date | 02.05.2016 |
| Hour | 10:00 › 11:00 |
| Speaker | Monique van der Wijst, University Medical Center, Groningen (NL) |
| Location | |
| Category | Conferences - Seminars |
SEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)
Abstract:
Mitochondrial diseases can be the result of sequence mutations in mitochondrial (mtDNA) or nuclear DNA (nDNA). In addition to such DNA mutations, epigenetic mutations affecting gene expression may also contribute to mitochondrial diseases. In this respect, most research focuses on epigenetic modifications of the nDNA. Alternatively, the discovery of a mitochondria-targeted DNA methyltransferase 1 in 2011, boosted the field of mitochondrial epigenetics. Since then, a few dozen of papers revealed the mitochondrial presence of other epigenetic enzymes, CpG and non-CpG methylation, and their link with aging and disease, among which cancer, diabetes and Alzheimer’s disease. To reveal the functional contribution of this epigenetic modification in the mtDNA, we have targeted several DNA methylating enzymes to the mtDNA. Subsequently, the effect of mtDNA methylation on mitochondrial gene expression, DNA replication and mitochondrial function was determined. Unraveling the impact of epigenetic regulation of the mtDNA will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.
Authorship:
Monique GP van der Wijst (1), A Mposhi (1, 2), AY van Tilburg (1), M G Rots (1)
1. Epigenetic Editing, Dept. Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1 9713 GZ Groningen, The Netherlands
2. Dept of Hepatology and Gastroenterology, University Medical Center Groningen, Hanzeplein 1 9713 GZ Groningen, The Netherlands.
Bio:
2007 – 2010: Radboud Universiteit Nijmegen, Bsc, Biomedical Sciences
2010 – 2012: Vrije Universiteit Amsterdam, Msc, Oncology
Sept. 2012 – Present: University Medical Center Groningen, Dept. Pathology & Medical Biology, Epigenetic Editing group, PhD student
Abstract:
Mitochondrial diseases can be the result of sequence mutations in mitochondrial (mtDNA) or nuclear DNA (nDNA). In addition to such DNA mutations, epigenetic mutations affecting gene expression may also contribute to mitochondrial diseases. In this respect, most research focuses on epigenetic modifications of the nDNA. Alternatively, the discovery of a mitochondria-targeted DNA methyltransferase 1 in 2011, boosted the field of mitochondrial epigenetics. Since then, a few dozen of papers revealed the mitochondrial presence of other epigenetic enzymes, CpG and non-CpG methylation, and their link with aging and disease, among which cancer, diabetes and Alzheimer’s disease. To reveal the functional contribution of this epigenetic modification in the mtDNA, we have targeted several DNA methylating enzymes to the mtDNA. Subsequently, the effect of mtDNA methylation on mitochondrial gene expression, DNA replication and mitochondrial function was determined. Unraveling the impact of epigenetic regulation of the mtDNA will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.
Authorship:
Monique GP van der Wijst (1), A Mposhi (1, 2), AY van Tilburg (1), M G Rots (1)
1. Epigenetic Editing, Dept. Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1 9713 GZ Groningen, The Netherlands
2. Dept of Hepatology and Gastroenterology, University Medical Center Groningen, Hanzeplein 1 9713 GZ Groningen, The Netherlands.
Bio:
2007 – 2010: Radboud Universiteit Nijmegen, Bsc, Biomedical Sciences
2010 – 2012: Vrije Universiteit Amsterdam, Msc, Oncology
Sept. 2012 – Present: University Medical Center Groningen, Dept. Pathology & Medical Biology, Epigenetic Editing group, PhD student
Practical information
- Informed public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx for the Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA)
Contact
- Kristina Schoonjans
IMPORTANT NOTICE: All external participants have to pass through SV Reception/Welcome Desk to be able to access to AI 1153. Contact person to call at arrival at SV Reception Desk: Johan Auwerx 30951 /Administrative Assistant: 39522.