Gentle and Robust Dyes for Dynamic Super-Resolution Imaging

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Event details

Date 12.10.2026
Hour 14:15 › 15:15
Speaker Dr. Zhixing Chen, Associate Professor, College of Future Technology, Peking University
Location
Category Conferences - Seminars
Event Language English
Abstract:

Live-cell imaging technology is advancing into the era of dynamic super-resolution imaging of organelles and specific proteins, placing new demands on the optical properties of fluorescent probes. Traditional live-cell fluorescent probes face two critical technical challenges:
  1. How to make fluorescent probes brighter and more photostable.
  2. How to make fluorescent probes gentler to minimize the photodamage of organelles.
Based on the fundamental principles of photochemistry and biochemistry, we have developed a new generation of live-cell imaging probes that far surpass traditional probes in brightness, photostability, and biocompatibility. These probes enable long-term super-resolution imaging of mitochondria, insulin vesicle secretion, plasma membrane dynamics, lysosomes, and more. Our representative achievements include: The PK Mito and PK Zinc dye series, widely used in mitochondrial and insulin secretion imaging. The BD series of novel fluorophores, in conjunction with self-labeling tags, offer general protein labeling strategies with superior optical properties compared to fluorescent proteins.

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Brief Biography:

Dr. Zhixing Chen, Associate Professor

College of Future Technology
Peking University

Dr. Zhixing Chen is a tenured associate professor at the College of Future Technology, Peking University. He received his BS from Tsinghua University in 2008 and his PhD from Columbia University in 2014. He subsequently completed postdoctoral training at Columbia University in 2015 and at Stanford University from 2016 to 2018.
The Chen Lab at Peking University was established in 2018. The lab endeavors to integrate chemistry and biochemistry to develop new imaging tools with high brightness, specificity, and biocompatibility, with the goal of advancing bioimaging technologies and enabling new approaches in cell biology, metabolism, and biophysics.

Website: https://zhixingchenlab.mysxl.cn/