Host genetic susceptibility to influenza A infections
Event details
| Date | 17.11.2010 |
| Hour | 14:00 |
| Speaker | Klaus SCHUGHART , Dept. Infection Genetics, Helmholtz Centre Infection Res., Hannover, Germany |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
To identify genetic determinants of host susceptibility and resistance, we studied the host response after infection with influenza A virus in various mouse genetic reference populations. We used several inbred mouse strains, recombinant inbred strains (BXD) and Interspecific Recombinant Congenic strains (BcG) as well as knock-out mutants. Mice were infected with influenza A H1N1 and H7N7 virus. Our studies demonstrated a large effect of the host genetic background on pathogenicity, viral reproduction and survival. Genetic mapping analyses are ongoing to determine the underlying genomic regions in the host. Furthermore, gene expression analysis and cytokine/chemokine profiles showed strong induction of inflammation-related genes in susceptible DBA/2J mice which contribute to a lethal outcome. We also performed a comprehensive analysis of the host-response to influenza virus infection by establishing a time series for the host transcriptome in C57BL/6J mice from days 1 to 14 post infection. Both cell-specific expression patterns as well as activation of specific pathways were discernible.
Practical information
- General public
- Free