How Coronaviruses Hijack ERAD tuning for replication?
Event details
| Date | 18.11.2010 |
| Speaker | Maurizio Molinari, Institute for Research in Biomedicine, Bellinzona |
| Category | Conferences - Seminars |
The endoplasmic reticulum (ER) contains folding machineries that assist maturation of newly synthesized polypeptides and ER-associated degradation (ERAD) machineries that remove non-native proteins. Uncontrolled ERAD interferes with protein maturation by inappropriate recognition and destruction of intermediates of ongoing folding programs. This is prevented, at steady state, by a series of events collectively defined as ERAD tuning that insure the selective removal of ERAD regulators from the ER lumen in LC3-I coated vesicles, the EDEMosomes.
Formation of these ER-derived vesicles is co-opted by positive strand RNA coronaviruses (CoVs) such as the severe acute respiratory syndrome (SARS)-CoV and mouse hepatitis virus (MHV) for the formation of double-membrane vesicles (DMVs) to which their replication and transcription complexes are anchored.
Formation of these ER-derived vesicles is co-opted by positive strand RNA coronaviruses (CoVs) such as the severe acute respiratory syndrome (SARS)-CoV and mouse hepatitis virus (MHV) for the formation of double-membrane vesicles (DMVs) to which their replication and transcription complexes are anchored.
Practical information
- General public
- Free
Organizer
- Gisou van der Goot