How to Transduce Force Into Biochemical Commands - Mechanosensing by Adhesion GPCRs
Event details
| Date | 17.02.2025 |
| Hour | 10:00 › 11:00 |
| Speaker | Prof. Tobias Langenhan, University of Leipzig (D) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
BIOENGINEERING SEMINAR
Abstract:
G protein coupled receptors (GPCR) have proven a treasure trove for modern pharmacological intervention of numerous human ailments. However, in stark contrast to classically targeted GPCRs, adhesion GPCRs have been largely neglected by biologists, pharmacologists and clinician scientists for decades. Only recently their physiological and signaling properties are being unravelled and show exciting features including their roles in tissue architecture, signaling through an intramolecular agonist, cell-autonomous and non-autonomous effects, and their unusual activation through mechanical cues. I will discuss the recent developments on adhesion GPCR signaling and introduce the receptor family as a topical area in neuroscience, immunology and cancer research.
Bio:
Positions:
Zoom link for attending remotely: https://epfl.zoom.us/j/67282214057?pwd=exiu9Wqa4DOaujh5uzD8Uc0Xh4ruWP.1
Abstract:
G protein coupled receptors (GPCR) have proven a treasure trove for modern pharmacological intervention of numerous human ailments. However, in stark contrast to classically targeted GPCRs, adhesion GPCRs have been largely neglected by biologists, pharmacologists and clinician scientists for decades. Only recently their physiological and signaling properties are being unravelled and show exciting features including their roles in tissue architecture, signaling through an intramolecular agonist, cell-autonomous and non-autonomous effects, and their unusual activation through mechanical cues. I will discuss the recent developments on adhesion GPCR signaling and introduce the receptor family as a topical area in neuroscience, immunology and cancer research.
Bio:
Positions:
- since 05/2023
Scientific co-director, University Cancer Center Leipzig, University Hospital Leipzig - since 03/2022
Adjunct professor, Institute of Biology, Faculty of Life Sciences, Leipzig University - since 10/2016
Full professor for Biochemistry, Chair of General Biochemistry, Rudolf Schönheimer Institute for Biochemistry, Medical Faculty, Leipzig University - 05/2016 - 09/2016
Heisenberg professor, Institute of Physiology & Comprehensive Heart Failure Center, Medical Faculty, University of Würzburg - 07/2009 - 04/2016
Group leader, Institute of Physiology, Medical Faculty, University of Würzburg
- 10/2005 - 06/2009
Doctoral studies in Neurosciences (D.Phil.), University of Oxford, UK - 09/2004 - 09/2005
Studies in Neuroscience, University of Oxford, UK - 09/2000 - 01/2006
Doctoral studies in Medicine (Dr. med.), University of Würzburg - 10/1997 - 06/2004
Studies in Medicine, University of Würzburg
Zoom link for attending remotely: https://epfl.zoom.us/j/67282214057?pwd=exiu9Wqa4DOaujh5uzD8Uc0Xh4ruWP.1
Practical information
- Informed public
- Free