Humoral control of mitochondrial function and longevity
Event details
| Date | 09.12.2011 |
| Hour | 16:00 |
| Speaker | Dr. Andrew Dillin |
| Location |
SV 1717a
|
| Category | Conferences - Seminars |
"Humoral control of mitochondrial function and longevity"
The endosymbiotically-derived relationship between the mitochondria and cell initially provided the cell with the energy necessary to allow for differentiation and to eventually enter into a state of complexity in which specialized organs and tissues could evolve. Two billion years later, whole organisms composed of complex networks of organs, tissues, and cells, are utterly dependent upon mitochondria for their energetic functions. In the face of an increasingly-complex environment, the eukaryotic cell now spends a considerable amount of mitochondrial-derived energy in an attempt to coordinate homeostasis and to minimize the potential for stochastic events to disrupt whole organism function. In consideration of this context, it seems logical that changes to the health of the mitochondria might initiate a signal that would need to be communicated to the whole organism. Certainly in mitotic tissues, mitochondria are essential for the initiation of the apoptotic pathways, and mitochondria are known to help signal metabolic states between tissues as well. But can mitochondria in one cell communicate with and affect mitochondrial function in distal cells? If so, how do the distal mitochondria hear and respond to such a signal?
Links
Practical information
- General public
- Free
Contact
- Prof. Johan Auwerx