Inference of Disease Genes from Protein Interactions in trans and cis
Event details
| Date | 14.03.2016 |
| Hour | 12:15 |
| Speaker | Prof. Jörg Gsponer, University of British Columbia (UBC), Vancouver (Can) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
(sandwiches served)
Abstract:
Protein interactions in trans and cis that activate or inhibit protein function play an important role in the fine-tuning of regulatory and signaling processes in the cell. In the first part of my presentation, I will show how we integrated data on protein interaction in trans with genomic information on risk genes of neurodegenerative diseases in order to identify genes that may increase the risk to develop any type of neurodegenerative disease when altered in expression or sequence. In the second part, I will introduce a computational approach for the identification of intrinsically disordered cis-regulatory elements (CREs), i.e., protein segments that regulate protein function via interactions in cis, and demonstrate that disease-causing mutations are highly enriched in predicted CREs, specifically mutations that are associated with different cancers.
Bio:
Education:
2003 – 2006
University of Cambridge (UK)
Post-doctoral Fellow, Computational Chemistry
1998 – 2003
University of Zurich (CH)
Doctor of Philosophy (PhD), Computational Biophysics
1991 – 1997
University of Lausanne (CH)
Doctor of Medicine (MD), Medicine
Positions:
2015 – Present
Roche, Basel (CH)
Visiting Professor
2015 – Present
University of British Columbia (UBC), Vancouver (Can)
Associate Professor
2009 – 2015
UBC, Centre for High-Throughput Biology (CHiBi)
Assistant Professor
2006 – 2009
MRC Laboratory of Molecular Biology, Cambridge (UK)
Research Fellow
(sandwiches served)
Abstract:
Protein interactions in trans and cis that activate or inhibit protein function play an important role in the fine-tuning of regulatory and signaling processes in the cell. In the first part of my presentation, I will show how we integrated data on protein interaction in trans with genomic information on risk genes of neurodegenerative diseases in order to identify genes that may increase the risk to develop any type of neurodegenerative disease when altered in expression or sequence. In the second part, I will introduce a computational approach for the identification of intrinsically disordered cis-regulatory elements (CREs), i.e., protein segments that regulate protein function via interactions in cis, and demonstrate that disease-causing mutations are highly enriched in predicted CREs, specifically mutations that are associated with different cancers.
Bio:
Education:
2003 – 2006
University of Cambridge (UK)
Post-doctoral Fellow, Computational Chemistry
1998 – 2003
University of Zurich (CH)
Doctor of Philosophy (PhD), Computational Biophysics
1991 – 1997
University of Lausanne (CH)
Doctor of Medicine (MD), Medicine
Positions:
2015 – Present
Roche, Basel (CH)
Visiting Professor
2015 – Present
University of British Columbia (UBC), Vancouver (Can)
Associate Professor
2009 – 2015
UBC, Centre for High-Throughput Biology (CHiBi)
Assistant Professor
2006 – 2009
MRC Laboratory of Molecular Biology, Cambridge (UK)
Research Fellow
Practical information
- Informed public
- Free
Organizer
- Profs. Bruno Correia & Sebastian Maerkl