Inhibitory Activities of Short Linear Motifs Underlie Hox Interactome Specificity in vivo
Event details
| Date | 18.06.2015 |
| Hour | 14:00 |
| Speaker | Samir Merabet, Ph.D., ENS, Lyon (F) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although our results remain to be functionally validated, they challenge the traditional role assigned to SLiMs and provide an alternative concept to explain how Hox interactome specificity could be achieved during the embryonic development.
Bio:
Current: Institut de Génomique Fonctionnelle de Lyon (IGFL), Lyon, France
Affolter Lab, Universität Basel, Switzerland
Centre national de la recherche scientifique, Paris, France
Université Aix-Marseille
Abstract:
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although our results remain to be functionally validated, they challenge the traditional role assigned to SLiMs and provide an alternative concept to explain how Hox interactome specificity could be achieved during the embryonic development.
Bio:
Current: Institut de Génomique Fonctionnelle de Lyon (IGFL), Lyon, France
Affolter Lab, Universität Basel, Switzerland
Centre national de la recherche scientifique, Paris, France
Université Aix-Marseille
Practical information
- Informed public
- Free