Lymph Node Homing of Lymphocytes and Dendritic Cells
Event details
| Date | 30.09.2013 |
| Hour | 12:15 › 13:15 |
| Speaker |
Prof. Reinhold Foerster, Hannover Medical School (D) Bio: At the Institute of Immunology, Prof. Dr. Reinhold Förster and his co-workers investigate the dynamic processes of the immune system during the immune response to pathogens. The main focus is on the function of chemokines and chemokine receptors for the space-time distribution of T-cells, B-cells and various kinds of dendritic cells. Processes of cellular differentiation, activation/suppression, as well as adhesion/communication, which are studied in vitro, but mainly in vivo with the help of mouse models, are also comprised. |
| Location | |
| Category | Conferences - Seminars |
DISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING
The continuous migration of DC and T cells from blood the periphery into draining lymph nodes is essential for the induction of protective immunity against pathogens as well as for the induction of tolerance towards harmless environmental antigens. It is well established that, following their activation, the chemokine receptor CCR7 plays a fundamental role in guiding skin-resident DC towards and into terminal lymphatics. We established recently intra lymphatic injections of immune cells into lymphatic vessels draining towards the popliteal lymph node in mice. Using this technique we could show that DCs enter the draining lymph node by directly penetrating the floor of subcapsular sinus and directionaly migrate into the T cell-rich paracortex. In contrast, naïve T cells arriving via afferent lymphatics home into lymph nodes via the medullary sinus. DCs require CCR7 to leave the subcapsular sinus and T cells rely on this receptor for trans-positioning from the medullary sinus into the lymph node parenchyma suggesting that these cells sense a gradient of CCR7-ligands. We now report how such a gradient is built and maintained in the subcapsular sinus of a lymph node.
The continuous migration of DC and T cells from blood the periphery into draining lymph nodes is essential for the induction of protective immunity against pathogens as well as for the induction of tolerance towards harmless environmental antigens. It is well established that, following their activation, the chemokine receptor CCR7 plays a fundamental role in guiding skin-resident DC towards and into terminal lymphatics. We established recently intra lymphatic injections of immune cells into lymphatic vessels draining towards the popliteal lymph node in mice. Using this technique we could show that DCs enter the draining lymph node by directly penetrating the floor of subcapsular sinus and directionaly migrate into the T cell-rich paracortex. In contrast, naïve T cells arriving via afferent lymphatics home into lymph nodes via the medullary sinus. DCs require CCR7 to leave the subcapsular sinus and T cells rely on this receptor for trans-positioning from the medullary sinus into the lymph node parenchyma suggesting that these cells sense a gradient of CCR7-ligands. We now report how such a gradient is built and maintained in the subcapsular sinus of a lymph node.
Links
Practical information
- Informed public
- Free
- This event is internal
Organizer
- Prof. Melody Swartz