MEchanics GAthering -MEGA- Seminar: Talk1 - Granular hydrogels as novel bioinks for 3D printing of artificial soft tissues; Talk2 - Immobilizing different types of drops in microfluidic devices
Cancelled
Event details
| Date | 12.03.2020 |
| Hour | 16:15 › 17:30 |
| Speaker | Matteo Hirsch & Mickael Kessler, Soft Materials Laboratory (SMaL), EPFL |
| Location | |
| Category | Conferences - Seminars |
Granular hydrogels as novel bioinks for 3D printing of artificial soft tissues, by Matteo Hirsch (SMaL, EPFL)
Hydrogels are among the first biomaterials expressly designed for their use in biomedicine. However, state-of-the-art applications of hydrogels are severely limited because they are typically either too soft or too brittle such that they cannot be used for load-bearing applications. At present, synthetic hydrogels are still far from reaching mechanical performances similar to that of their biological counterparts. One of the main reasons behind this difference is their poor internal arrangement. Indeed, nature is able to fabricate soft biological tissues encompassing highly ordered, hierarchical structures with locally varying compositions. Inspired by nature, we propose to use microgels as building blocks for the fabrication of 3D printed granular materials. Moreover, we investigate the effect of different processing parameters on the rheological behavior of jammed microgel solutions and on the mechanical performance of granular hydrogels.
Immobilizing different types of drops in microfluidic devices, by Mickael Kessler (SMaL, EPFL)
Many natural materials display unique mechanical properties that are, at least in parts, a result of the locally varying compositions of these materials. (1) Bio-inspired materials usually cannot reach similar sets of mechanical properties than their natural counterparts. A contributing reason for this difference is that they typically possess homogeneous compositions. A possibility to fabricate soft, structured materials with locally varying compositions is the use of reagent-loaded drops as building blocks. (2) In my talk, I will present a microfluidic device that allows immobilization of drops loaded with different reagents at well-defined positions. Thereby, this device offers possibilities to control the local composition of the resulting materials. I will show how we can vary the trapping force of such traps to achieve a selective immobilization of only one type of drops. I will further present a mathematical model that predicts the trapping strength of traps depending on their geometry, which facilitates the design of such devices. To conclude, I will demonstrate an example of how immobilized drops can be transformed into soft materials with locally varying composition. This technology offers new possibilities to design bio-inspired structured hydrogels with improved mechanical properties.
(1) Harrington, M. J., Masic, A., Holten-Andersen, N., Waite, J. H. & Fratzl, P. Iron-clad fibers: a metal-based biological strategy for hard flexible coatings. Science 328, 216–20 (2010).
(2) Priemel, T., Degtyar, E., Dean, M. N. & Harrington, M. J. Rapid self-assembly of complex biomolecular architectures during mussel byssus biofabrication. Nat. Commun. 8, 14539 (2017).
(3) Brakke, Kenneth A. 1992. The surface evolver. Experiment. Math. 1
(4) Dangla, R., Lee, S. & Baroud, C. N. Trapping Microfluidic Drops in Wells of Surface Energy. Phys. Rev. Lett. 107, 124501 (2011).
Hydrogels are among the first biomaterials expressly designed for their use in biomedicine. However, state-of-the-art applications of hydrogels are severely limited because they are typically either too soft or too brittle such that they cannot be used for load-bearing applications. At present, synthetic hydrogels are still far from reaching mechanical performances similar to that of their biological counterparts. One of the main reasons behind this difference is their poor internal arrangement. Indeed, nature is able to fabricate soft biological tissues encompassing highly ordered, hierarchical structures with locally varying compositions. Inspired by nature, we propose to use microgels as building blocks for the fabrication of 3D printed granular materials. Moreover, we investigate the effect of different processing parameters on the rheological behavior of jammed microgel solutions and on the mechanical performance of granular hydrogels.
Immobilizing different types of drops in microfluidic devices, by Mickael Kessler (SMaL, EPFL)
Many natural materials display unique mechanical properties that are, at least in parts, a result of the locally varying compositions of these materials. (1) Bio-inspired materials usually cannot reach similar sets of mechanical properties than their natural counterparts. A contributing reason for this difference is that they typically possess homogeneous compositions. A possibility to fabricate soft, structured materials with locally varying compositions is the use of reagent-loaded drops as building blocks. (2) In my talk, I will present a microfluidic device that allows immobilization of drops loaded with different reagents at well-defined positions. Thereby, this device offers possibilities to control the local composition of the resulting materials. I will show how we can vary the trapping force of such traps to achieve a selective immobilization of only one type of drops. I will further present a mathematical model that predicts the trapping strength of traps depending on their geometry, which facilitates the design of such devices. To conclude, I will demonstrate an example of how immobilized drops can be transformed into soft materials with locally varying composition. This technology offers new possibilities to design bio-inspired structured hydrogels with improved mechanical properties.
(1) Harrington, M. J., Masic, A., Holten-Andersen, N., Waite, J. H. & Fratzl, P. Iron-clad fibers: a metal-based biological strategy for hard flexible coatings. Science 328, 216–20 (2010).
(2) Priemel, T., Degtyar, E., Dean, M. N. & Harrington, M. J. Rapid self-assembly of complex biomolecular architectures during mussel byssus biofabrication. Nat. Commun. 8, 14539 (2017).
(3) Brakke, Kenneth A. 1992. The surface evolver. Experiment. Math. 1
(4) Dangla, R., Lee, S. & Baroud, C. N. Trapping Microfluidic Drops in Wells of Surface Energy. Phys. Rev. Lett. 107, 124501 (2011).
Practical information
- General public
- Free
Organizer
- MEGA.Seminar Organizing Committee