Metabolic signaling: role of nuclear and membrane receptors
Event details
| Date | 28.11.2014 |
| Hour | 12:30 › 13:30 |
| Speaker | Dr Kristina Schoonjans, GR-SCH, IBI, SV, EPFL |
| Location | |
| Category | Conferences - Seminars |
Abstract:
My interest is to understand the molecular basis by which metabolites in general, and bile acids in particular, signal to convey adaptive responses in metabolic organs. I will illustrate this principle by two vignettes. The first focuses on the nuclear receptor, liver receptor homolog 1, for which we identified roles in multiple processes, ranging from the control of bile acid composition to the regulation of liver intermediary metabolism.
In this talk I will describe the molecular mechanism how a selective gain-of-function mutation of LRH-1 that disrupt its SUMOylation on a single residue, enhances bile acid secretion and reverse cholesterol transport, which on a systemic level translates in a remarkable protection against atherosclerosis. My second example will focus on the bile acid-activated GPCR, TGR5, which we established as vital for energy expenditure, glucose homeostasis and macrophage inflammation in the vessel wall. I will show how TGR5 activation reduces chemokine expression in macrophages via mTOR-dependent enhanced translation of the dominant-negative C/EBP-LIP isoform and decreases the recruitment of macrophages to the adipose tissue, thereby contributing to the insulin sensitization induced by bile acids.
Through focusing on metabolite sensing pathways my laboratory has hence identified novel mechanisms that contribute to the pathogenesis of common metabolic disorders, such as type 2 diabetes and atherosclerosis. We hope that these insights one day can be applied to develop new preventive and therapeutic strategies for these pervasive diseases.
Bio:
Kristina Schoonjans is Lecturer in Biochemistry and Research Professor at the Ecole Polytechnique Fédérale in Lausanne (EPFL), Switzerland, where she studies the role of nuclear and membrane receptors in metabolism and bile acid signalling. She obtained her Ph.D in Molecular Biology and Pharmacology from the University of Lille, France in 1995 for her work on the role of the PPAR nuclear receptor family in metabolism. She continued her academic career in the same research area during her postdoctoral training at the Institut Pasteur de Lille until 1999. She then moved to the Institut de Génétique de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg first as a research scientist and later in 2007 as a research director with INSERM. Kristina Schoonjans is member of the editorial board of Molecular Endocrinology and Molecular and Cellular Endocrinology.
My interest is to understand the molecular basis by which metabolites in general, and bile acids in particular, signal to convey adaptive responses in metabolic organs. I will illustrate this principle by two vignettes. The first focuses on the nuclear receptor, liver receptor homolog 1, for which we identified roles in multiple processes, ranging from the control of bile acid composition to the regulation of liver intermediary metabolism.
In this talk I will describe the molecular mechanism how a selective gain-of-function mutation of LRH-1 that disrupt its SUMOylation on a single residue, enhances bile acid secretion and reverse cholesterol transport, which on a systemic level translates in a remarkable protection against atherosclerosis. My second example will focus on the bile acid-activated GPCR, TGR5, which we established as vital for energy expenditure, glucose homeostasis and macrophage inflammation in the vessel wall. I will show how TGR5 activation reduces chemokine expression in macrophages via mTOR-dependent enhanced translation of the dominant-negative C/EBP-LIP isoform and decreases the recruitment of macrophages to the adipose tissue, thereby contributing to the insulin sensitization induced by bile acids.
Through focusing on metabolite sensing pathways my laboratory has hence identified novel mechanisms that contribute to the pathogenesis of common metabolic disorders, such as type 2 diabetes and atherosclerosis. We hope that these insights one day can be applied to develop new preventive and therapeutic strategies for these pervasive diseases.
Bio:
Kristina Schoonjans is Lecturer in Biochemistry and Research Professor at the Ecole Polytechnique Fédérale in Lausanne (EPFL), Switzerland, where she studies the role of nuclear and membrane receptors in metabolism and bile acid signalling. She obtained her Ph.D in Molecular Biology and Pharmacology from the University of Lille, France in 1995 for her work on the role of the PPAR nuclear receptor family in metabolism. She continued her academic career in the same research area during her postdoctoral training at the Institut Pasteur de Lille until 1999. She then moved to the Institut de Génétique de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg first as a research scientist and later in 2007 as a research director with INSERM. Kristina Schoonjans is member of the editorial board of Molecular Endocrinology and Molecular and Cellular Endocrinology.
Practical information
- Informed public
- Free
Organizer
- SV Faculty
Contact
- Dr Hirling / M. Mary